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The usefulness of growth hormone treatment for psychological status in young adult survivors of childhood leukaemia: an open-label study |
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| Authors: | Jaap Huisman Eline J Aukema Jan Berend Deijen Silvia CCM van Coeverden Gertjan JL Kaspers Heleen JH van der Pal Henriette A Delemarre-van de Waal |
| Affiliation: | (1) Department of Medical Psychology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands;(2) Department of Clinical Neuropsychology, VU University, van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands;(3) Department of Pediatrics, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands;(4) Department of Medical Oncology, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands;(5) Psychosocial Department, Emma Children's Hospital/Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands;(6) Department of Public and Occupational Health, EMGO-institute, van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands |
| Abstract: | BackgroundTo reduce the risk of brain damage children with acute lymphoblastic leukaemia (ALL) are nowadays mainly treated with intrathecal chemotherapy (ITC) instead of central nervous system (CNS) radiation therapy (CRT) to prevent CNS relapse. However, chemotherapy may also lead to cognitive deficits. As growth hormone deficiency (GHD) or impaired growth hormone secretion are frequently found in ALL patients treated with cranial radiation therapy and/or chemotherapy, we hypothesized that GH therapy may reduce cognitive deficits in these patients. |
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