酮体代谢在颅脑创伤中对脑组织的神经保护作用

【摘要】〓外伤性脑损伤后造成脑组织缺血缺氧,继发炎症、脑血肿、脑肿胀、脑水肿、颇内压升高等一系列病理生理学变化。在颅脑创伤中,继发性颅脑损伤是引起急性病情恶化和招致病人死亡、致残的主要原因。颅脑创伤后会出现葡萄糖代谢障碍,从而影响神经元的代谢和能量来源。生酮饮食是一种高脂肪、低碳水化合物、低蛋白的饮食治疗方案,机体主要依靠脂肪而不是碳水化合物来供应能量,已用于临床抗癫痫的治疗,其有效性和安全性已得到国际公认。近来有报道证实颅脑创伤后生酮饮食可以延缓细胞调亡,起到神经保护作用,并能减轻脑水肿。现就酮体代谢对颅脑创伤后的神经保护作用进行综述。

Neuroprotective effect of ketone metabolism on brain during times of traumatic brain injury

【Abstract】〓Traumatic brain injury could resulted in hypoxia-ischemia of brain tissue. It would lead to a series of pathophysiological changes,.including secondary inflammation,.cephalophyma, encephaledema, increased intracranial pressure..Secondary brain injury is the primary cause of deterioration of diseases and death or disability of patients..The post traumatic glucose metabolic disturbance can worsen the metabolic condition of neuron. Ketone diet is a diet therapy with high fat, low carbohydrates and protein. The energy source of body comes from lipometabolism instead of carbohydrates. The ketogenic diet had been applied in clinical antiepileptic therapy. The late research demonstrates that ketogenic diet post-traumatically could affect the neuron apoptosis. It could also alleviate the brain edema to protect the neuron. In this paper, we would review the neuroprotective effect of ketone metabolism on brain post traumatic brain injury.