| 1-磷酸鞘氨醇受体的研究进展 |
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| 引用本文： | 石小岩,廖爱军. 1-磷酸鞘氨醇受体的研究进展[J]. 实用药物与临床, 2016, 0(4): 506-509. DOI: 10.14053/j.cnki.ppcr.201604032 |
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| 作者姓名： | 石小岩 廖爱军 |
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| 作者单位： | 中国医科大学附属盛京医院血液科,沈阳,110004 |
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| 基金项目： | 国家自然科学基金(81272629) |
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| 摘 要： | 1-磷酸鞘氨醇S1P(Sphingosine 1-phosphate,S1P)是调节细胞内外多种生物学功能的重要信号分子之一,作用于S1P受体后,在很多生理和病理过程中发挥重要的调节作用。Sphk-S1P-S1PR信号通路及其在炎症、肿瘤、动脉粥样硬化、自体免疫系统疾病、神经系统疾病等多种疾病中的作用已成为目前研究的热点之一。越来越多的S1P受体调节剂被研发。
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| 关 键 词： | S1P S1P受体 Sphk-S1P-S1PR信号通路 S1P受体调节剂 |
Research progress on the receptors of the S1 P |
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| Abstract: | S1P is one of the important signal molecules which can regulate many biological functions inside and outside the cells. It plays an important role in regulating many physiological and pathological processes after being combined with S1P receptors. Sphk-S1P-S1PR signaling pathway has become a hot spot in the current research on in-flammation, cancer, atherosclerosis, autoimmune system diseases, nervous system diseases and so on. More and more regulators of S1PRs are being developed. |
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| Keywords: | Sphingosine 1-phosphate(S1P) S1P receptors Sphk-S1P-S1PR signaling pathway Regulators of S1P receptors |
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