血清降钙素原对中枢神经系统感染性疾病的诊断价值

目的探讨血清降钙素原(PCT)、C-反应蛋白(CRP)、外周血白细胞计数对中枢神经系统感染性疾病的诊断价值。方法采用半定量固相免疫测定法测定31例中枢神经系统感染性疾病患者(细菌性感染组18例,非细菌性感染组13例)血清PCT浓度,免疫散射速率比浊法测定CRP,常规方法检测外周血白细胞。结果血清PCT对中枢神经系统细菌感染诊断的敏感度为100.0%,特异度为76.9%,优于CRP(P=0.001),与白细胞计数阳性率比较,差异无统计学意义(P>0.05)。结论血清PCT测定是中枢神经系统细菌感染的有效指标。

Diagnosis value of serum procalcitonin in central nervous system infection

Objective To evaluate the diagnosis value of serum procalcitonin (PCT),C-reactive protein(CRP) and white blood cell (WBC) in patients with central nervous system infection. Methods Serum PCT was determined by semi-quantitative solid-phase immunoassay from 31patients with central nervous system infection(18 with bacterial and 13 with non-bacterial). CRP was measured by using immunity-turbidity method and WBC was counted by routine method. Results The sensitivity of PCT was 100.0% and the specificity was 76.9% for the diagnosis of patients with bacterial central nervous system infection .There was no significant difference between PCT and WBC(P= 0.673 ),PCT had higher sensitivity and specificity than CRP(P=0.001). Conclusions Serum PCT is an effective indication of bacterial central nervous system infection .