血清S100B蛋白联合降钙素原在初筛中枢神经系统感染中的应用价值

目的：明确检测血清S100B蛋白联合降钙素原是否在初筛中枢神经系统感染中具有重要临床价值。方法：以我院急诊抢救室及急诊留院观察疑似中枢神经系统感染的159例患者为研究对象,按患者入院时采集基本信息及血液标本并行腰椎穿刺术进行相关的检查检验。将患者按是否存在中枢神经系统感染分为中枢神经系统感染组（CNS＋组）、无中枢神经系统感染组（CNS-组）,分析各组患者血清PCT、S100B蛋白浓度,评价PCT联合S100B蛋白在初筛中枢神经系统感染的应用价值。结果：CNS＋组患者血清PCT的浓度高于CNS-组,CNS＋组患者血清S100B蛋白的浓度明显高于CNS-组。在PCT初筛阳性患者中有50%患者为中枢神经系统感染感染,而在S100B初筛阳性患者中有91.4%的患者存在中枢神经系统感染,而在PCT和S100B初筛阳性的患者全部存在中枢神经系统感染,在PCT和S100B初筛阴性的患者有45.3%存在中枢神经系统感染。结论：检测血清PCT和S100B浓度可以提高中枢神经系统感染的诊断能力。

The clinical value of SIOOB protein and procalcitonin for screening infection of central nervous system

Objective：The aim of this study was to determine whether S100B protein and procalcitonin in serum has important clinical value in screening central nervous system infection. Method： 159 patients with suspected central nervous system infection from the emergency department and emergency observation of our hospital were selected as the object of this research. Basic information of patients,blood samples and CSF samples were collected at the time after admission. The patients were divided into central nervous system infection group（CNS＋ group） and no central nervous system infection group（CNS- group）. The levels of PCT,S100B protein in serum were implemented in order to evaluate the clinical value for screening infection of central nervous system. Result：The concentrations of serum PCT in GNS＋ group was higher than CNS- group,the concentrations of serum S100B protein in CNS＋ group was higher than CNS- group. 50 ~ of patients with positive screening of PCT only had CNS infection;91.4 % of patients with positive screening of S100B only had CNS infection. All patients with positive screen- ing of PCT ＆ S100B had GNS infection and 45.3 % of patients with negative PCT % S100B screening had CNS infection. Conclusion：The concentrations of serum PCT % S100B can improve the diagnostic accuracy of the central nervous system infections.