肺泡表面活性蛋白D对慢性阻塞性肺疾病的生物标记作用

目的探讨肺泡表面活性蛋白D(SPD)在慢性阻塞性肺疾病(COPD)的进展及预后判断中的生物标记作用。方法比较COPD急性加重期和稳定期患者SPD浓度的差异,比较急性加重期患者治疗前后SPD浓度的变化,进行圣乔治呼吸问卷(SGRQ),并分析治疗后COPD急性加重期患者血清SPD与SGRQ之间的关系。结果 COPD急性加重期患者血清SPD浓度显著高于稳定期患者,治疗后急性加重期患者血清SPD浓度显著低于治疗前,血清SPD浓度与SGRQ之间呈显著正相关。结论血清SPD有望成为一种肺特异性生物标记物在COPD的发展进程、治疗效果和预后判断中发挥作用。

Biomarker Role of Pulmonary Surfactant Protein-D for Chronic Obstructive Pulmonary Disease

Objective To explore biomarker role in the progress and prognosis of the pulmonary surfactant protein-D(SPD) in chronic obstruction of lung disease(COPD). Methods To compare the difference of SPD concentration between patients of AECOPD and stability COPD,and between the patients of AECOPD before and after treatments.To survey SGRQ and to analyse the relationship between SPD and SGRQ after the treatment in AECOPD. Results SPD concentration of AECOPD was significant above the stability of the patients.SPD concentration after the treatment in AECOPD was significantly lower than before treating.Serum SPD concentration and SGRQ was notably positively related. Conclusion The SPD will become a lung special biological mark to play a role in the development process,healing effect and prognosis of COPD.