增殖细胞核抗原在血管瘤及血管畸形组织中的表达

了解血管瘤的不形态学类和同一类不同时期的内皮细胞增殖情况。方法采用免疫组织化学方法对４１例不同形态学类型的血管瘤标本进行了增殖细胞核抗原的检测和比较。其中包括婴幼儿期血管瘤标本２９例及成人期标本１２例。结论ＰＣＮＡ的表达对血管瘤的分类，诊断及治疗选择都有意义。

Expression of proliferating cell nuclear antigen in hemangioma and vascular malformations]

OBJECTIVE: This study was to compare the proliferative activity of endothelial cells of various types of hemangiomas and vascular malformations in different phases. METHODS: Forty-one specimens of hemangiomas or vascular malformations from biopsy or operative resection were stained with immunohistochemical method for proliferating cell nuclear antigen (PCNA). The proliferative activity of endothelial cells was expressed by labeling index (LI). RESULTS: PCNA was positive in all of proliferating strawberry, composite hemangiomas and some of cavernous hemangiomas in children. PCNA was negative in all of adult involuted hemangiomas and some of cavernous hemangiomas in children. There were no statistically significant differences in labeling indices of PCNA between various types of proliferating hemangiomas in children while there were statistically significant differences between child proliferating hemangiomas and involuted hemangiomas in children or all of adult hemangiomas. CONCLUSION: The results may be helpful to answer some bewildering questions about hemangiomas and provide a basis for new classification.