烧伤中心细菌耐药性分析

研究烧伤中心广泛应用第三代头孢菌素背景下细菌耐药性。方法 采用纸片扩散法。结果 ２５９株革兰氏阴性杆菌对头孢噻肟，头胞曲松，头孢哌酮和头孢他啶全部耐药的菌株占３１％，头孢酮／舒巴坦可使５２％耐药菌株恢复敏感性。伊米配能和环丙沙星对铜绿假单力，无硝不动杆菌，肠杆菌科耐药率分别为２３．８％和５１．２％，２８．６％和２１．４％，９．９％和２０．４％。

An analysis of bacterial resistance to antimicrobial agents in a burn centre]

OBJECTIVE: To investigate bacterial resistance to antimicrobial agents in the background of extensive employment of third-generation cephalosporins in the treatment of burn infection. METHODS: Bacterial susceptibility testing was carried out using Kirby-Bauer method. RESULTS: Out of 259 Gram negative bacilli isolates, 31% of these strains were all resistant to cefotaxime, ceftriaxone, cefoperazone and ceftazidime. In vitro test, susceptibility of 52% third-generation cephlosporins resistant strains were restored by cefoperazone/sulbactum. 23.8% of P. aeruginosa were resistant to imipenem, 51.2% to ciprofloxacin. 28.6% of A. anitratum were resistant to imipenem, 21.4% to ciprofloxacin. 9.9% of enterobacteriaceae were resistant to imipenem, 20.4% to ciprofloxacin. 26.9% of MRSA were resistant to imipenem, 73% to ciprofloxacin. No norvancomycin resistance was detected. 2.7% of E. faecalis were resistant to norvancomycin. CONCLUSION: It is likely that the observed resistance to third-generation cephalosporins may be partially due to chromosome-mediated type-1 beta- lactamase.