| 慢性乙型肝炎患者外周血淋巴细胞上CXCR3表达的初步观察 |
| |
| 引用本文： | 史丽云,张立煌,李明伟. 慢性乙型肝炎患者外周血淋巴细胞上CXCR3表达的初步观察[J]. 细胞与分子免疫学杂志, 2003, 19(4): 380-382 |
| |
| 作者姓名： | 史丽云 张立煌 李明伟 |
| |
| 作者单位： | 1. 浙江大学,医学院免疫学研究所,浙江,杭州,310016
2. 浙江大学附属一院传染病研究所,浙江,杭州,310006 |
| |
| 摘 要： | 目的：探讨趋化性细胞因子受体CXCR3在慢性乙型肝炎症发生机制中的作用。方法：采用流式细胞术，检测炎症活动程度不同患者外周血淋巴细胞表面CXCR3的表达，及其在CD4^ 和CD8^ T细胞上的分布。结果：慢性乙肝患者外周血CXCR3^ 淋巴细胞和单核细胞明显增多，以CXCR3^ CD8^ T细胞的增加更明显。结论：趋化因子受体CXCR3与其配体的相互作用，可能在募集淋巴细胞及炎症形成过程中有重要作用。
|
| 关 键 词： | 趋化性细胞因子受体 CXCR3 慢性乙型肝炎 |
| 文章编号： | 1007-8738(2003)04-380-03 |
| 修稿时间： | 2003-04-01 |
Preliminary observation of CXCR3 expression on peripheral blood lymphocytes from patients with chronic hepatitis B infection |
| |
| SHI Li yun ,ZHANG Li huang ,LI Ming wei Immunology Institute. Preliminary observation of CXCR3 expression on peripheral blood lymphocytes from patients with chronic hepatitis B infection[J]. Chinese journal of cellular and molecular immunology, 2003, 19(4): 380-382 |
| |
| Authors: | SHI Li yun ZHANG Li huang LI Ming wei Immunology Institute |
| |
| Affiliation: | Institute of Immunology, The First Affiliated Hospital, Zhejiang University, Hangzhou 310016, China. |
| |
| Abstract: | AIM: To explore the role of chemokine receptor CXCR3 in pathogenesis of chronic hepatitis B. METHODS: The expression of CXCR3 on peripheral blood lymphocytes from chronic hepatitis B patients with various degrees of inflammation was detected, and the distributions of CXCR3 on CD4 + and CD8 + T lymphocytes were also evaluated by FACS. RESULTS: As compared with healthy controls, the percentages of CXCR3 + lymphocytes, monocytes and CD8 + T cells were increased significantly in chronic hepatitis B patients. CONCLUSION: Above data suggest that chemokine receptor CXCR3 may play an important role in the recruitment of lymphocytes, especially CTLs recruited to inflammation sites. |
| |
| Keywords: | chemokine receptor CXCR3 chronic hepatitis B |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
