熊去氧胆酸治疗非酒精性脂肪肝30例临床观察

目的观察熊去氧胆酸治疗非酒精性脂肪肝的疗效。方法非酒精性脂肪肝患者分为治疗组30例，应用熊去氧胆酸钠胶囊（优思弗胶囊）250mg，每日3次，口服，疗程为6个月。对照组30例，应用多烯磷脂胆碱胶囊（易善复胶囊）456mg，每日3次，口服，疗程为6个月。观察治疗前后肝脏B超、生化指标、肝脏大小和症状变化。结果治疗后肝脏B超、生化学指标、症状明显改善，与易善复比较无统计学意义，无明显不良反应。结论熊去氧胆酸治疗非酒精性脂肪肝安全有效，值得临床推广使用。

The Therapeutic Effect of Ursodeoxycholic Acid in Treatment of Nonalcoholic Fatty Liver: A Clinical Observation of 30 Cases

Objective To investigate the efficacy of ursodeoxycholie acid in the treatment of nonalcoholic fatty liver. Methods Sixty cases with non-alcoholic fatty liver were divided into two groups with 30 cases in each, the treatment group of 30 cases which received ursodeoxycholie acid capsules of 250mg, 3 times a day, oral ingestion, treatment for 6 months, and control group of 30 cases which received polyene phosphoryleholine capsule （ Essentiale capsules ） of 456mg, 3 times a day oral ingestion, treatment for 6 months. The change of B-scan liver, biochemical parameters, liver size and the symptoms were xamined before and after the treatment. Results Essentiale, liver ultrasonography, biochemical indicators, symptoms of treatment group significantly improved after the treatment .There was no statistical significance between the two groups.ursodeoxycholic acid was no significant adverse reaction. Conclusion Using ursodeoxycholie acid and treating non-alcoholic fatty liver is very safe and effective, worthy in clinical widely.