阿奇霉素、甲基泼尼松龙、人血丙种球蛋白治疗难治性支原体肺炎疗效观察

目的探讨阿奇霉素、甲基泼尼松龙、人血丙种球蛋白治疗难治性支原体肺炎（RMPP）的临床疗效。方法70例难治性支原体肺炎患儿随机分成治疗组和对照组各35例，治疗组35例RMPP患者均给予阿奇霉素静脉或口服治疗3个疗程，同时联合应用甲基泼尼松龙针、人血丙种球蛋白针，对照组35例患者仅应用阿奇霉素治疗，观察对比两组的临床疗效。结果与对照组比较，治疗组的总有效率达90％以上，明显高于对照组71．4％，差异有显著性（P〈0．05）。治疗组咳嗽消失时间、退热时间、肺部哕音消失时间及住院时间均分别短于对照组，差异有显著性（P〈0．05）。结论足量、足疗程选用大环内脂类抗生素如阿奇霉素，同时对病情严重者早期联合应用激素、丙种球蛋白等治疗难治性支原体肺炎疗效确切，临床预后良好，值得临床推广和应用。

Clinical Treatment Analysis on Refractory Mycoplasma Pneumoniae Pneumonia

Objective To explore the azithromycin, methylprednisolone, human serum gamma globulin combination treatment refractory mycoplasma pneumoniae pneumonia （ RMPP ）. Methods All 70 patients were randomly divided into treatment group and control group 35 cases respectly, the treatment group of 35 patients were given intravenous or oral azithromycin treatment for 3 cycles, while the combination of methylprednisolone needle, people gamma globulin needle, the control group of 35 patients applied only azithromycin, and to compare the two groups clinical efficacy. Results Compared with the control group, the total effective rate of treatment group was 90% above, significantly higher than 71.4% （ P 〈 0.05 ）. Cough treatment group lost time, cooling time, pulmonary rales disappeared all the time and hospital stay of the treatment group were shorter than the control group （P 〈 0.05 ）. Conclusion Earlily diagnose and treat, full dosage and enough course of treatment with Macrolide antibiotics, united with hormone and gamma globulin to aim directly at severe patients, and strengthened combined therapy.