No major effect of orciprenaline and propranolol upon ACTH-induced cortisol secretion. |
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| Authors: | A Nonell S Kerk F Lederbogen D Kopf B Hamann S Lewicka M Deuschle |
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| Affiliation: | Central Institute of Mental Health, Mannheim, Germany. |
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| Abstract: | Preclinical research suggests adrenal beta-adrenergic receptors to be involved in the regulation of steroid synthesis. In a group of healthy male volunteers, we compared ACTH-induced cortisol and dehydroepiandrosterone (DHEA) secretion after pre-treatment with orciprenaline, propranolol or placebo. Neither baseline nor ACTH-induced steroid secretion differed between these conditions. Our data do not support the hypothesis that the adrenal beta-receptor plays a major role in steroid secretion in humans. |
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