氟比洛芬酯超前镇痛对肱骨骨折患者术后镇痛的影响

目的:观察氟比洛芬酯用于骨科手术时超前镇痛的作用效果。方法:将96例ASA I～Ⅱ级行肱骨骨折手术的患者随机分为观察组和对照组。观察组术前15min静脉缓注氟比洛芬酯1mg/kg;对照组术前15min静脉缓注脂微球注射液0.1 mL/kg。所有受试患者术后均行患者自控静脉镇痛(PCIA)。分别记录术后2h、4h、6h、12h、24h的视觉模拟评分(VAS)、24h芬太尼用量和不良反应,并在镇痛结束后统计患者对镇痛治疗的总体满意度。结果:术后2h、4h、6h、12h、24hVAS评分观察组与对照组差异无统计学意义(P>0.05);术后24h观察组的芬太尼用量(580.4±38.2)μg低于对照组的(720.7±47.6)μg(P<0.05);两组不良反应发生率的差异有统计学意义(P<0.05);两组患者对镇痛治疗总体满意度(Ⅴ级)差异有统计学意义(P<0.05)。结论:肱骨骨折手术超前应用氟比洛芬酯,能减少术后芬太尼的用量,减轻不良反应的发生,并能提高患者对镇痛治疗的总体满意度。

Preemptive analgesic effect of flurbiprofen axetii on patients with fracture of humerus after surgery

Objective: To observe the preemptive analgesic effect of flurbiprofen axetil on postoperative pain relief.Methods:Ninety-six humerus fracture patients(ASA I-Ⅱ) with surgery were randomly assigned into two groups.The patients in group I(n=48) received intravenous injection of flurbiprofen axetil 1 mg/kg 15 min before surgery,and those in groupⅡ(n=48) had intravenous injection of placebo 0.1 mL/kg.Postoperative analgesia efficacy was assessed by visual analog scales(VAS) at2 h,4 h,6 h,12 h,24 h after surgery.Fentanyl requirements and adverse effects were recorded at 24 h after surgery.The overall satisfaction to analgesic therapy was evaluated.Results: There was no significant difference in VAS between two groups at 2 h,4 h,6 h,12 h,24 h(P>0.05).Requirements of fentanyl were significantly low in group I (580.4±38.2) μg] than those in groupⅡ(720.7±47.6) μg](P<0.05).There was significant difference between the two groups in adverse effects(P< 0.05).Conclusions: Flurbiprofen axetil can produce preemptive effect,reduce the requirements of fentanyl and the adverse effect,and enhance the quality of analgesia.