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| 姜黄素体外对阴道乳酸杆菌及精子动态参数的影响 | |
| 引用本文： | 夏承来,粱颖,关秉恩,黄汉辉. 姜黄素体外对阴道乳酸杆菌及精子动态参数的影响[J]. 海南医学院学报, 2012, 18(6): 748-750 |
| 作者姓名： | 夏承来 粱颖 关秉恩 黄汉辉 |
| 作者单位： | 广州医学院第三附属医院药剂科,广东广州,510150 |
| 基金项目： | 广东省人口与计划生育委员会项目 |
| 摘 要： | 目的:研究姜黄素体外对人阴道乳酸杆菌及精子动态参数的影响。方法:XTT检测姜黄素对包皮角朊细胞的细胞毒性作用;TPY液体培养基法检测姜黄素体外对人阴道乳酸杆菌的抑菌作用。并用CASA法检测加入姜黄素前后精液各项参数的变化。结果:姜黄素抑制人阴道乳酸杆菌的MIC为(12.5±1.2)mg/mL,10mg/mL的姜黄素使精子活率、A活力、A+B活力、直线速度VSL、平均路径VAP都降低。直线性LN、摆动性WOB增加,都具有差异性。结论:一定浓度的姜黄素体外可能降低精子的活力。 |
| 关 键 词： | 姜黄素 避孕 阴道乳酸杆菌 精液 |
In vitro influence of curcuma on vaginal lactobacillus and sperm motility parameters |
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| XIA Cheng-lai , LIANG Ying , GUAN Bing-en , HUANG Han-hui. In vitro influence of curcuma on vaginal lactobacillus and sperm motility parameters[J]. Journal of Hainan Medical College, 2012, 18(6): 748-750 | |
| Authors: | XIA Cheng-lai LIANG Ying GUAN Bing-en HUANG Han-hui |
| Affiliation: | 1 (Department of Pharmacy,the Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China) |
| Abstract: | Objective: To explore the in vitro influence of curcuma on vaginal lactobacillus and sperm motility parameters.Methods: The cytoxicity of curcuma to foreskin keratinocytes was tested by XTT.The inhibition of curcuma to lactobacillus was tested by TPY liquid medium method.Human sperm was treated with 10 mg/mL curcuma and the sperm motility parameters were tested by CASA-SS 3.0.Results: The MIC of curcuma to lactobacillus was(12.5±1.2) mg/mL.The sperm activity、A activity、A+B activity、VSL and VAP were decreased by curcuma.The LN and WOB were increased by curcuma.Conclusion: Curcuma could decrease the sperm activity in vitro. |
| Keywords: | Curcuma Contraception Vaginal lactobacillus Sperm |
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