血清表皮生长因子受体在乳腺癌中的表达及临床意义

目的:探讨血清表皮生长因子受体(EGFR)的表达与乳腺癌的预防、发生、发展、预后之间的关系。方法:采用酶联免疫法(ELISA)检测健康体检组(50例)、乳腺良性肿瘤组(87例)和乳腺恶性肿瘤组(89例)血清EGFR的表达量,比较不同组、良性肿瘤组不同类型患者以及不同临床分期恶性肿瘤组患者血清EGFR表达的差异。结果:恶性肿瘤组患者血清EGFR水平较良性肿瘤组和健康组明显升高(P<0.05),而良性肿瘤组和健康组差异无统计学意义(P>0.05);良性肿瘤组不同类型患者治疗前、后血清EGFR水平的比较:乳腺大导管乳头状瘤患者术前和术后14d均比乳腺囊性增生病和乳腺纤维瘤的水平高,差异有统计学意义(P均<0.05),术后6个月差异无统计学意义(P>0.05),乳腺囊性增生病和乳腺纤维瘤在各个时间点差异均无统计学意义(P>0.05);不同临床分期恶性肿瘤组患者EGFR水平的比较:除术前Ⅳ期同0期相比和术后6个月Ⅲ期同0期、Ⅰ期相比差异有统计学意义(P均<0.05)外,其余各项比较差异均无统计学意义(P>0.05)。结论:血清EGFR的高表达与乳腺癌的发生、发展有关,但尚不能确立为独立的预测和预后指标,需要更多的临床研究进一步证实。

Expression and significance of epidermal growth factor receptor in breast carcinoma patients

Objective: To explore the expression levels of epidermal growth factor receptor(EGFR)and its relationship with the occurence,progression and prognosis of breast cancer.Methods:The serum EGFR levels of 50 health women,87 patients with benign breast tumor patients and the 89 patients with malignant breast tumors were detected by ELISA method.The differences in the expression levels among the three groups were analyzed.Results:Patients with malignant breast tumors had significantly increased serum EGFR level(P<0.05),comparing with both health women group and benign breast disease patients;while there was no significant difference in EGFR between health women and patients with benign breast diseases(P>0.05).As for patients with benign tumor,those with breast intraductal papilloma had significantly higher level of EGFR than the breast cystic hyperplasia patients and breast intracanalicular fibroma patients both before surgery and 14 d after surgery(P<0.05),while the difference was not significant 6 months after surgery(P>0.05).There was no significant difference in serum EGFR between patients with breast cystic hyperplasia and patients with breast intracanalicular fibroma(P>0.05) in all different time-point.The difference in EGFP was significant between patients during the preoperative Ⅳ period and patients during 0 period,and significant between patients during postoperative Ⅲ and patients during 0 period,Ⅰperiod(P<0.05).Conclusion:Though over-expressed EGFR may be related to occurence and progression of breast cancer,it can only be considered as independent predicative index.It still need more clinical research evidence.