| 114例质子泵抑制剂不良反应病例分析 |
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| 引用本文： | 梁茂本,孟祥梅. 114例质子泵抑制剂不良反应病例分析[J]. 中国药物警戒, 2013, 10(1): 39-41 |
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| 作者姓名： | 梁茂本 孟祥梅 |
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| 作者单位： | 南京医科大学附属淮安第一医院,江苏,淮安,223300 |
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| 摘 要： | 目的探讨质子泵抑制剂(PPI)不良反应(ADR)的特点及相关因素,为临床合理用药提供参考。方法利用"维普医药信息镜像系统"、"万方数据医药信息镜像系统"、"中国医院数字图书馆",对2001年1月~2011年12月国内公开报道的PPI所致的114ADR例进行统计分析。结果 114例ADR患者中男性72例(63.16%),女性42例(36.84%),奥美拉唑最高79例(69.30%),临床主要表现为精神神经系统、消化系统、心血管系统等。结论临床应高度重视PPI的ADR,以确保安全用药。
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| 关 键 词： | 质子泵抑制剂 不良反应 文献 |
Analysis of 114 Cases of ADR Induced by PPI |
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| LIANG Mao-ben , MENG Xiang-mei. Analysis of 114 Cases of ADR Induced by PPI[J]. Chinese JOurnal of Pharmacovigilance, 2013, 10(1): 39-41 |
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| Authors: | LIANG Mao-ben MENG Xiang-mei |
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| Affiliation: | (Huai’an First People’s Hospital,Nanjing Medical University,Jiangsu Huai’an 223300,China) |
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| Abstract: | Objective To explore the features and contributing factors of adverse drug reaction（ADR） induced by proton pump inhibitors （PPIs） and provide rational use of drugs in clinic. Methods A statistical analysis was conducted on 114 cases of ADR publicly reported during the year from January 2001 to December 2011 via the use of VIP Medical Information System（VMIS）, Wanfang Medical Information System, and Chinese Hospital Digital Database. Results Of all the 114 cases, male patients amount to 72, accounting for 63.16%; Female 42 cases, comprising 36.84%. The ADR induced by Omeprazole reach up to 79 cases, making up 69.30%, and clinic ADR is mainly observed on the nervous system, the digestive system and the cardiovascular system. Conclusion High importance should be attached to the ADR induced by PPIs in clinic to ensure the safe use of drugs. |
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| Keywords: | PPI ADR literature |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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