上皮性卵巢癌患者血清可溶性白细胞介素-2受体、人附睾蛋白4、T淋巴细胞亚群水平及临床意义

目的探讨上皮性卵巢癌患者的血清可溶性白细胞介素-2受体(SIL-2R)、人附睾蛋白4(HE4)、T淋巴细胞亚群水平及临床意义。方法选择100例上皮性卵巢癌患者和100例卵巢良性肿瘤患者,分别作为观察组和对照组,比较两组患者的血清SIL-2R、HE4及T淋巴细胞亚群(CD3⁺、CD4⁺、CD8⁺和CD4⁺/CD8⁺)水平,分析不同临床特征上皮性卵巢癌患者的血清SIL-2R、HE4及T淋巴细胞亚群水平。结果观察组患者的血清SIL-2R、HE4水平均明显高于对照组,差异均有统计学意义(P﹤0.01)。观察组患者的血清CD3⁺、CD4⁺水平及CD4⁺/CD8⁺均明显低于对照组,CD8⁺水平明显高于对照组,差异均有统计学意义(P﹤0.01)。临床分期为Ⅲ~Ⅳ期、中/低分化、有腹腔积液的上皮性卵巢癌患者的血清SIL-2R、HE4水平分别高于临床分期为Ⅰ~Ⅱ期、高分化、无腹腔积液的患者,差异均有统计学意义(P﹤0.01)。中/低分化、有淋巴结转移、有腹腔积液上皮性卵巢癌患者的血清CD3⁺、CD4⁺水平分别低于高分化、无淋巴结转移、无腹腔积液的患者,CD8⁺水平分别高于高分化、无淋巴结转移、无腹腔积液的患者,差异均有统计学意义(P﹤0.05)。上皮性卵巢癌患者的血清SIL-2R、HE4水平与CD3⁺、CD4⁺、CD4⁺/CD8⁺均呈负相关(P﹤0.05),与CD8⁺呈正相关(P﹤0.05)。结论上皮性卵巢癌患者血清中SIL-2R、HE4水平均较高,T淋巴细胞亚群CD3⁺、CD4⁺水平及CD4⁺/CD8⁺均较低,SIL-2R、HE4水平与T淋巴细胞亚群之间具有相关性。

Serum levels of soluble interleukin-2 receptor,human epididymal protein 4 and T lymphocyte subsets in patients with epithelial ovarian cancer and their clinical significance

Objective To investigate the serum levels of soluble interleukin-2 receptor(SIL-2R),human epididymal protein 4(HE4)and T lymphocyte subsets in patients with epithelial ovarian cancer and their clinical significance.Method 100 patients with epithelial ovarian cancer and 100 patients with benign ovarian tumors were selected as the observation group and the control group,respectively.The serum levels of SIL-2R,HE4 and T lymphocyte subsets(CD3⁺,CD4⁺,CD8⁺and CD4⁺/CD8⁺)were compared between the two groups.The serum levels of SIL-2R,HE4 and T lymphocyte subsets in patients with epithelial ovarian cancer with different clinical characteristics were analyzed.Result The levels of serum SIL-2R and HE4 in the observation group were significantly higher than those in the control group(P<0.01).The levels of serum CD3⁺,CD4⁺,and CD4⁺/CD8⁺in the observation group were significantly lower than those in the control group,while the level of CD8⁺in the observation group was significantly higher than that in the control group(P<0.01).The levels of serum SIL-2R and HE4 in patients with clinical stage Ⅲ-Ⅳ,moderate/low differentiation,and ascites were significantly higher than those in patients with clinical stage Ⅰ-Ⅱ,well differentiation and no ascites,the differences were statistically significant(P<0.01).The levels of serum CD3⁺,CD4⁺in patients with moderate/low differentiation,lymph node metastasis,and ascites were significantly lower than those in patients with well differentiation,no lymph node metastasis and no ascites,the levels of serum CD8⁺in patients with moderate/low differentiation,lymph node metastasis,and ascites were significantly higher than those in patients with well differentiation,no lymph node metastasis and no ascites,the differences were statistically significant(P<0.05).The levels of serum SIL-2R and HE4 in patients with epithelial ovarian cancer were negatively correlated with CD3⁺,CD4⁺and CD4⁺/CD8⁺(P<0.05),and positively correlated with CD8⁺(P<0.05).Conclusion The serum levels of SIL-2R and HE4 in patients with epithelial ovarian cancer are high,while the levels of T lymphocyte subsets CD3⁺,CD4⁺and CD4⁺/CD8⁺are low.There is a correlation between SIL-2R,HE4 levels and T lymphocyte subsets.