Clinical features and treatment prognosis of infertile males with robertsonian translocation

BACKGROUND: The principle of treating male infertility in those with chromosomal aberrations should change according to progress in treatment modalities. METHODS: In this study, ten patients with Robertsonian translocation were assessed for their cytogenetic and clinical characteristics to establish guidelines for treating these patients. RESULTS: In 8 of 10 cases, chromosomes 13 and 14 were involved. In 4 of 10 cases (40%), their wives became pregnant, including two spontaneously. All newborns were without any deformities including one boy who was shown to have a normal karyotype. CONCLUSION: Infertility treatment of patients with Robertsonian translocation should be optimistically performed on the basis of proper informed consent.