血清对氧磷酯酶联合氧化低密度脂蛋白在缺铁性贫血的临床意义

目的探讨血清对氧磷酯酶1（PON1）在缺铁性贫血中的意义。方法测30例缺铁性贫血（IDA）患者血清PON1和氧化低密度脂蛋白（OX-LDL）的水平，并与33例健康对照组比较。结果30例IDA患者PON1值为78．9±6．4U／L，明显低于对照组PON1（147．1±8．2U／L）；而OX-LDL水平为640．1±168．9μg/L，明显高于健康对照组（390．9±199．6μg／L），差别具有统计学意义（P〈0．01）。相关性分析发现，IDA组PON1活性与OX-LDL含量存在明显的负相关（r=-0．598，P〈0．01）。结论PON1活性下降，OX-LDL升高．提示IDA患者体内抗氧化防御体系缺陷，脂质发生过氧化反应，存在动脉粥样硬化的高风险。

Clinical Significance of Paraoxonaseland Oxidized Low Density Lipoprotein in Patients with Iron Deficiency Anemia

Objeetive To study the clinical significance of Paraoxonasel （PONI） and Oxidized low density lipoprotein （ox- LDL） in patients with iron deficiency anemia （IDA）. Methods PONland ox-LDL of 30 eases with IDA and 33 normal control subjects were measured and compared. Results The PON1 level of patients （78.9±6.4U/L） was significantly lower than that in nomml control group （147.1 ± 8.2 U/L）. However, the cases had nmrkedly higher level of ox-LDL （640.1 ± 168.9 U/L） comparing with the control group （390.9 ± 199.6U/L） （p 〈 0.01 ）. Correlation analysis indicated that there was a negative correlation between the activity of PON1 and the level of ox-LDL in patients with IDA （r = - 0.598, p 〈 0.01 ）. Condusion Decreased activity of PON1 and increased level of ox-LDL can indicate that the antioxidant defense system is defect which is susceptible to lipid per-oxldation and atherosclerosis.