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| 血小板输注无效患者的血小板抗体检测 | |
| 引用本文： | 李岚,张爱根,李妙珊. 血小板输注无效患者的血小板抗体检测[J]. 中国现代医学杂志, 2008, 18(15): 2227-2228,2231 |
| 作者姓名： | 李岚 张爱根 李妙珊 |
| 作者单位： | 深圳市第二人民医院,输血科,广东,深圳,518035 |
| 摘 要： | 目的 分析临床血小板输注无效的主要原因,并寻找解决的方法.方法 应用酶联免疫吸附试验(ELISA),对213例临床发生血小板输注无效(PTR)的病人进行血小板抗体检测和鉴定.结果 血小板抗体阳性71例(33.33%),其中人类白细胞抗原(human leucocyte antigen,HLA)抗体阳性65例(30.51%);血小板特异性抗原即人类血小板抗原(human platelet antigen,HPA)抗体阳性2例(0.94%);HLA和HPA抗体并存4例(1.88%).结论 HLA抗体是导致PTR的主要免疫因素.对患者进行"适合性血小板榆注",可逆转血小板榆注无效状态,提高血小板输注的安全性和疗效. |
| 关 键 词： | 血小板抗体 血小板输注无效 血小板交叉配合试验 |
Platelet antibody detection of PTR patients |
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| LI Lan,ZHANG Ai-gen,LI Miao-shan. Platelet antibody detection of PTR patients[J]. China Journal of Modern Medicine, 2008, 18(15): 2227-2228,2231 | |
| Authors: | LI Lan ZHANG Ai-gen LI Miao-shan |
| Abstract: | [Objective] To analyze the reason of Platelet Transfusion Refractoriness (PTR) and search the solution. [Method] The platelet antibody in 213 cases of PTR patients were detected and identified by using ELISA. [Results] 71 (33.33%) cases were platelet antibody positive, including 65 (30.51%) cases of Human Leukocyte Antigen (HLA) antibody positive. 2 (0.94%) cases of Human Platelet Antigen (HPA) antibody positive, and 4 (1.88%) cases with both HLA antibody and HPA antibody. [Conclusion] HLA antibody is the m... |
| Keywords: | platelet antibody platelet transfusion refractoriness platelet compatible cross-matching |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |