Synthesis and radioreceptor binding activity of N-0437, a new, extremely potent and selective D<sub>2</sub> dopamine receptor agonist期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis and radioreceptor binding activity of N-0437, a new, extremely potent and selective D₂ dopamine receptor agonist

Authors:	A. S. Horn P. Tepper J. Van Der Weide M. Watanabe D. Grigoriadis P. Seeman

Affiliation:	(1) Department of Pharmacy, University of Groningen, Ant. Deusinglaan 2, 9713 AW Groningen, The Netherlands;(2) Department of Pharmacology, University of Toronto, M5S1A8 Toronto, Canada

Abstract:	The synthesis of a new, potent and selective D₂ dopamine receptor agonist, N-0437, of the 2-aminotetralin group is described. The results of a radioreceptor binding assay using a homogenate of porcine anterior pituitary as a tissue source for D₂ dopamine receptors and³H-spiperone as radioligand demonstrate that this compound is one of the most potent compounds so far evaluated in this test system.

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