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Midazolam is metabolized by at least three different cytochrome P450 enzymes |
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| Authors: | WANDEL, C. BOCKER, R. BOHRER, H. BROWNE, A. RUGHEIMER, E. MARTIN, E. |
| Affiliation: | Department of Anaesthesia, University of Heidelberg D-69120 Heidelberg, Germany Department of Pharmacology, University of Erlangen D-91054 Erlangen, Germany Department of Anaesthesia, University of Erlangen D-91054 Erlangen, Germany |
| Abstract: | Distribution volumes and metabolism determine the pharmacokineticsof midazolam. Cytochrome P450 3A4 has been considered a significantenzyme in its metabolism. Using heterologously expressed cytochromeP450 enzymes, we have confirmed the additional involvement ofcytochromes P450 3A3 and 3A5 in the hydroxylation of the midazolam.Whereas cytochrome P450 3A3 metabolized midazolam to the sameextent as cytochrome P450 3A4, cytochrome P450 3A5 increasedits metabolism by a factor of 2.7. The relationship of |
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