不同源性及不同参数精子对ICSI结局的影响

目的:研究不同源性精子、不同参数精子及冻融精子对ICSI结局的影响。方法:接受ICSI治疗的510对不育夫妇共进行了517个周期,分为6组。射出精液少弱畸精子症组(A组)82例,共进行85个周期;射出精液严重少弱精子症组(B组)170例,共进行174个周期;附睾细针穿刺抽吸精子组(C组)108例,共进行108个周期;睾丸细针穿刺抽吸精子组(D组)71例,共进行71个周期;冻融射出精子组(E组)34例,共进行34个周期;冻融附睾睾丸精子组(F组)45例,共进行45个周期;比较其妊娠结局。结果:6组患者一般情况比较无统计学差异(P>0.05),6组患者的受精率、优胚率、临床妊娠率、早期流产率无统计学差异(P>0.05)。结论:不同源性精子、不同参数精子及冻融精子对ICSI结局无明显影响。

Fertilization and Pregnancy Outcome with Intracytoplasmic Sperm Injection Using Ejaculate Sperm, Surgically Retrieved Sperm and Frozen-thawed Sperm

Objective: To compare the fertilization and pregnancy outcome in intracytoplasmic sperm injection using sperm from ejaculates semen, epididymal sperm, testicular sperm and frozen-thawed sperm. Methods: Patients were divided into six groups according to the quality and source of sperm. Patients in group A (n=82)underwent 85 cycles of ICSI using ejaculated abnormal semen, group B(n=170) underwent 174 cycles using ejaculated highly abnormal semen, group C(n=108) underwent 108 cycles using epididymal sperm, group D(n=71) underwent 71 cycles using testicular sperm, group E(n=34) underwent 34 cycles using frozen-thawed ejaculated sperm, group F(n=45) underwent 45 cycles using frozen-thawed epididymal and testicular sperm. Results: No difference was observed among six groups in fertilization rate, the top quality embryo rate, pregnancy rate and early abortion rate. Conclusion: There was no significant difference in fertilization and pregnancy outcome in intracyto-plasmic sperm injection using different quality and source of sperm.