2型糖尿病合并认知功能障碍的相关因素分析

目的：研究2型糖尿病（T2DM）合并认知功能障碍的相关危险因素。方法：选择2型糖尿病患者198例为调查对象，以简易智能精神状态量表（MMSE）对每位受检者的认知功能进行评定，将患者分为认知功能障碍组和认知功能正常组，比较两组的一般状况及临床资料。进行非条件logistic回归分析认知功能障碍的相关因素。结果：认知功能障碍组相对于认知功能正常组在年龄、病程、DM家族史、高血压病史、餐后2h血糖、糖化血红蛋白、CHO、尿UMA、是否存在抑郁、焦虑、是否合并DM视网膜病变、DM周围神经病变以及是否使用胰岛素治疗、是否坚持运动等方面的差别具有统计学意义。进行非条件logistic回归分析，共6个变量进入方程：年龄、抑郁、HbA1C、CHO、DM视网膜病变、是否坚持运动。结论：年龄、抑郁、血糖控制不好、高胆固醇、并发DM视网膜病变均是T2DM合并认知功能障碍的独立危险因素．而峰持运动则是保护因素．

Type 2 diabetes mellitus with cognitive dysfunction related factors analysis

Objective： To study type 2 diabetes mellitus（T2DM） with cognitive dysfunction related risk factors. Methods： Selected 198 patients with type 2 diabetes as the investigation object, Mini-mental- Mental State Examination（MMSE） was used to assess each slected subject＇s cognitive function. The patients were divided into cognitve dysfunction group and cognitive function group. The general state and clinical date between those two groups were compared,and Non Condition logistic regression was used analysis the related factors of cognitive dysfunction. Results： The differences in age, disease, DM family history, hypertension, 2h postprandial blood glucose, glycosylated hemoglobin, CHO, urinary UMA, the existence of depression,anxiety,whether the merger of DM retinopathy, DM peripheral neuropathy, whether the use of insulin therapy,and whether insist to exercise between cognitive dysfunction group and cognitive function group had statistical significance.Non-Condition logistic regression analysis involve six variables into the equation which were Age, Depression,HbA1C,CHO, DM retinopathy,whether or not adhere to exercise. Conclusion： Age,depression, poor blood sugar control,high cholesterol,and DM complicated by reitno pathy in type 2 DM are acknowleged as independent risk factors of T2DM with cognitive dysfunction,while insist on exercise is the protective factor.