姜黄属中药活血化瘀功效关联物质研究进展

姜黄、莪术、片姜黄和郁金均属于姜黄属中药,是临床常用活血化瘀代表药,多用于治疗瘀血阻滞引起的闭经痛经,胸痹心痛,风湿痹痛等.现代研究表明,姜黄属中药中的标识性成分姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素、莪术二酮、吉马酮、莪术醇及β-榄香烯等均具有改善血液流变性、抗血小板聚集、抗血栓、抗炎、抗肿瘤、抗纤维化等活血化瘀作...

Efficacy-related substances of blood-activating and stasis-resolving medicinals derived from Curcuma plants:a review

Derived from Curcuma plants,Curcumae Longae Rhizoma,Curcumae Rhizoma,Wenyujin Rhizoma Concisum,and Curcumae Radix are common blood-activating and stasis-resolving medicinals in clinical practice,which are mainly used to treat amenorrhea,dysmenorrhea,chest impediment and heart pain,and rheumatic arthralgia caused by blood stasis block.According to modern research,the typical components in medicinals derived from Curcuma plants,like curcumin,demethoxycurcumin,bisdemethoxycurcumin,curdione,germacrone,curcumol,andβ-elemene,have the activities of hemorheology improvement,anti-platelet aggregation,anti-thrombosis,anti-inflammation,anti-tumor,and anti-fibrosis,thereby activating blood and resolving stasis.However,due to the difference in origin,medicinal part,processing,and other aspects,the efficacy and clinical application are different.The efficacy-related substances behind the difference have not yet been systematically studied.Thus,focusing on the efficacy-related substances,this study reviewed the background,efficacy and clinical application,efficacy-related substances,and"prediction-identification-verification"research method of blood-activating and stasis-resolving medicinals derived from Curcuma plants,which is expected to lay a theoretical basis for the future research on the"similarities and differences"of such medicinals based on integrated evidence chain and to guide the scientific and rational application of them in clinical practice.