无高尿酸血症的2型糖尿病患者血尿酸与骨骼肌指数的相关性分析

目的:探讨无高尿酸血症的2型糖尿病（T2DM）患者血尿酸与骨骼肌指数（SMI）的相关性。方法:为横断面研究。纳入2013年6月至2015年12月在重庆医科大学附属第一医院内分泌内科住院的1 104例T2DM患者，并收集所有患者的临床资料。采用双能X线骨密度仪评估身体成分，并计算SMI，SMI=四肢肌肉质量/身高 ...

Correlation analysis between serum uric acid and skeletal muscle index in patients with type 2 diabetes mellitus without hyperuricemia

Objective To investigate the association of skeletal muscle index(SMI)and serum uric acid(UA)in patients with type 2 diabetes mellitus(T2DM)without hyperuricemia in a cross-sectional study.Methods Body composition was assessed by dual-energy X-ray-absorptiometry among 1104 patients with T2DM hospitalized in the Department of Endocrinology of the First Affiliated Hospital of Chongqing Medical University from June 2013 to December 2015.Clinical data were collected for statistical analysis.Muscle mass reducing was defined as SMI less than 7.0 kg/m² in men or 5.4 kg/m² in women.The subjects were divided into the non-decreased muscle mass group and the decreased muscle mass group according to their muscle mass,and the subgroups of different genders were analyzed.The association of SMI and UA was investigated by simple regression and multiple linear regression.Results In total 1104 patients,900 were included in the non-decreased muscle mass group,and 204 were included in the decreased muscle mass group.The level of UA was statistically different between patients without and with muscle mass reducing[(318.5±90.7)vs.(282.1±92.1)μmol/L,P<0.01].Grouped by gender,the statistically significant difference remained[men:(336.3±88.6)vs.(299.0±93.7)μmol/L,P<0.01;women:(294.9±88.1)vs.(259.9±85.6)μmol/L,P<0.01].UA was positively and statistically significantly associated with SMI in patients with T2DM in simple linear regression(β=0.294,P<0.01).Grouped by gender,the relationship remained in simple linear regression(men:β=0.209,P<0.01;women:β=0.208,P<0.01).After adjusting for age,body mass index,diabetic foot,creatinine,high-density lipoprotein-cholesterol,hemoglobin,neutrophil percentage,hypersensitive C-reactive protein,smoking history,metformin history,UA was positively and statistically significantly associated with SMI in patients with T2DM(β=0.052,P=0.022).UA was positively and statistically significantly associated with SMI in women(β=0.087,P=0.012),and it was negatively but not statistically significantly associated with SMI in men(β=-0.005,P=0.857).Conclusions UA is positively associated with SMI in patients with T2DM without hyperuricemia,suggesting that there may be a relationship between UA and the occurrence of muscle mass reducing in T2DM.