基质金属蛋白酶及其抑制剂与后发性白内障发生的关系

基质金属蛋白酶(MMPs)是一类依赖金属锌离子存在而获得催化活性的锌金属蛋白酶超家族,由正常组织细胞或肿瘤细胞合成、分泌,其作用较为广泛,在创伤愈合和肿瘤发生中起降解细胞外基质的作用.正常机体存在内源性的基质金属蛋白酶抑制剂(TIMPs),可以调节MMPs的活性.根据来源不同,MMPs抑制剂分为:TIMPs、天然MMPs抑制剂和人工合成的MMPs抑制剂.MMPs与TIMPs的表达失衡参与了肿瘤、类风湿性关节炎、后发性白内障(PCO)等病理过程,已有研究证实PCO患者MMP-2和MMP-9表达增加.现将MMPs及其抑制剂的分类、功能特点进行归纳总结,并对其与PCO发生的关系进行综述.

The relationship between matrix metalloproteinase,matrix metalloproteinase inhibitors and posterior capsular opacification

Matrix metalloproteinases (MMPs) are a group of zinc-dependent proteolytic enzymes able to cleave all major protein components in the extracellular matrix during the processes of wound healing and tumor formation.Tissue inhibitors of MMPs (TIMPs),which exist in the human body,can regulate the activity of MMPs.According to different sources,MMP inhibitors are divided into TIMPs,natural MMP inhibitors and synthetic inhibitors.The classification and functional features of MMPs and MMP inhibitors are summarized and the relationship between MMPs,MMP inhibitors and posterior capsular opacification (PCO) are reviewed.