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| Neuron-specific Enclose and Myelin Basic Protein in Cerebrospinal Fluid of Patients with First Episode Schizophrenia | |
| 引用本文： | 李淑英 吴汉荣 郭慧荣 赵峥. Neuron-specific Enclose and Myelin Basic Protein in Cerebrospinal Fluid of Patients with First Episode Schizophrenia[J]. 华中科技大学学报(医学英德文版), 2006, 26(2): 228-230. DOI: 10.1007/BF02895823 |
| 作者姓名： | 李淑英 吴汉荣 郭慧荣 赵峥 |
| 作者单位： | Department of Children and Adolescent Health Maternity and Children Health Care，Tongji Medical College Huazhong University of Science and Technology Wuhan 430030，China，Department of Psychiatry of First Affiliated Hospital of Zhengzhou University Zhengzhou 450052，China，Department of Children and Adolescent Health Maternity and Children Health Care，Tongji Medical College Huazhong University of Science and Technology Wuhan 430030，China，Department of Psychiatry of First Affiliated Hospital of Zhengzhou University Zhengzhou 450052，China，Henan Province Mental Hospital，Xinxiang 453000，China |
| 摘 要： | Schizophrenia , the most common disease ofmental illness , was regarded as functional diseasewithout organic change in the past . But recently ,more and more evidenceindicates that there are or-ganic changes in patients with schizophrenia , withthe advance of neuropathology and neuroi mag-ing[1 ,2].But it is unknown whether these organicchanges are caused by congenital aplasia or ac-quired brain damage[1]. Since 1980 s , many re-searchers reported that neuron-specific enclose(NSE) and myelin … |
| 关 键 词： | 髓磷脂 神经元 神经分裂症 病理机制 |
| 收稿时间： | 2005-01-19 |
Neuron-specific enclose and myelin basic protein in cerebrospinal fluid of patients with first episode schizophrenia |
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| Li Shuying,Wu Hanrong,Guo Huirong,Zhao Zheng. Neuron-specific enclose and myelin basic protein in cerebrospinal fluid of patients with first episode schizophrenia[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2006, 26(2): 228-230. DOI: 10.1007/BF02895823 | |
| Authors: | Li Shuying Wu Hanrong Guo Huirong Zhao Zheng |
| Affiliation: | 1. Department of Children and Adolescent Health, Maternity and Children Health Care, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Psychiatry of First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 2. Department of Children and Adolescent Health, Maternity and Children Health Care, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 3. Department of Psychiatry of First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 4. Henan Province Mental Hospital, Xinxiang 453000, China |
| Abstract: | In order to study whether patients with schizophrenia have cerebral injury, neuron-specific enolase (NSE) and myelin basic protein (MBP)in cerebrospinal fluid (CSF) of 33 patients with first episode schizophrenia and 9 from the control group were determined by double antibody sandwich enzyme immunoassay method. The results showed that there was significant difference in the NSE contents between the experimental group and control group (P<0.01). The NSE contents in CSF in the experimental group were positively correlated with MBP in schizophrenia patients (P<0.05). These findings suggested that patients with schizophrenia had cerebral injury. |
| Keywords: | schizophrenia cerebrospinal fluid neuron specific enolase myelin basic protein |
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