生物可完全降解封堵器封堵犬卵圆孔未闭的实验研究

目的 评估生物可完全降解卵圆孔未闭（patent foramen ovale，PFO）封堵器封堵犬PFO的可行性、安全性等。方法 右胸小切口开胸卵圆窝穿刺法建立犬PFO模型，即刻在直视及经胸超声心动图（TTE）引导下用生物可完全降解型PFO封堵器封堵PFO。在植入后分别于1、3、6、9和12个月各处死2只犬，进行肉眼和组织学检查。结果 10只犬成功建立PFO模型后并植入可完全降解PFO封堵器。随访见封堵器均未发生移位，表面无赘生物及血栓形成，大体解剖见内膜组织从边缘逐渐完全覆盖封堵器表面。组织病理学提示，术后6个月封堵器骨架几乎完全降解并和周围组织融为一体。结论 应用生物可完全降解PFO封堵器封堵犬PFO，降解后在体内无任何残留物，是一种安全、有效并且可行的封堵器。

Animal experimental study of the fully biodegradable patant foramen ovale (PFO) occluder

AIM To evaluate the feasibility, safety of a fully biodegradable occluder for closure of patent foramen ovale (PFO) in an acute canine model. METHODS The PFO was created in healthy canine by a homemade PFO perforator and the PFO was closed immediately by the fully biodegradable PFO occluder. Animals were sacrificed at 1, 3, 6, 9 and 12 months after procedure. RESULTS Acute PFO models were successfully created in 10 dogs and occluders was successfully implanted in the PFO model. The cardiac gross anatomy revealed that all occluders were stable in the fossa ovale and no vegetation or thrombosis formation was observed on the surface of all occluders. The endothelial tissue gradually covered from the edge of the surface of occluder. Different periods of pathological observations suggested that the skeleton of occluder is almost completely degraded and integrated with the host tissue at 6 month follow-up. CONCLUSION The present investigation applied fully biodegradable occluder to close PFO in a canine model and no residue was identified in the body after degradation.This is a safe, effective and feasible method of closing the PFO and the efficacy was similar when compared to a metal occluder.