纳米制剂在糖尿病创面愈合中的应用研究

由于高血糖引起代谢障碍导致的氧化应激、感染、血管病变、炎症和神经病变，使得糖尿病（diabetes mellitus,DM）患者往往伤口愈合不良，发生糖尿病足溃疡（diabetic foot ulcers,DFUs），严重的可导致截肢。通过对糖尿病创面愈合过程和病理生理学的深入了解，可以获得治疗创伤损伤的有效策略。近年来，纳米制剂在加速糖尿病伤口愈合中有广泛的应用。一方面纳米颗粒有利于伤口愈合，另一方面可用于递送一种或多种治疗药物，如生长因子、核酸、抗生素和抗氧化剂，使它们可以在目标组织内持续释放。本文综述了近年来各种纳米制剂在促进糖尿病创面愈合方面的应用和作用机制。

Application of nanoparticles in wound healing of diabetes

Due to oxidative stress, infection, vascular disease, inflammation and neuropathy caused by metabolic disorders induced by hyperglycemia, Diabetes mellitus (DM) patients often suffer from poor wound healing and develop diabetic foot ulcers (DFUs), which may even lead to amputation in severe cases.Through the deep understanding of the diabetic wound healing process and its pathophysiology, effective strategies for the treatment of wound injury can be obtained.Nano-preparation has been widely used in accelerating wound healing in recent years.On the one hand, nanoparticles are beneficial for diabetic wound healing; on the other hand, they can be used to deliver one or more therapeutic agents such as growth factors, nucleic acids, antibiotics and antioxidants, which can be continuously released within the target tissue.This paper reviews the application and mechanism of various nano-preparation in promoting diabetic wound healing.