Risk assessment of atherosclerotic plaques based on global biomechanics |
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| Authors: | Simone Melchionna Giorgio Amati Massimo Bernaschi Mauro Bisson Sauro Succi Dimitrios Mitsouras Frank J. Rybicki |
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| Affiliation: | 1. IPCF – CNR, Consiglio Nazionale delle Ricerche, P.le A. Moro 2, 00185 Rome, Italy;2. CASPUR, Via dei Tizii, 6, 00185 Roma, Italy;3. IAC – CNR, Consiglio Nazionale delle Ricerche, Via dei Taurini 1, 00185 Rome, Italy;4. Applied Imaging Science Laboratory, Department of Radiology, Brigham and Women''s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, USA |
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| Abstract: | ![]()
We present the results of a computational study of the entire left coronary system simulated both at Newtonian level and at red blood cell resolution for a sizeable number of physiological conditions. We analyze the cardiovascular implications of stenotic plaques and show that the standard clinical criterion for surgical or percutaneous intervention, based on the fractional flow reserve (FFR), is significantly affected by system-dependent, local hemodynamic factors. A refined version, based on the new notion of local FFR response to stenotic growth, and accounting for statistical uncertainties due to flow heterogeneity, is suggested and illustrated. |
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| Keywords: | Fractional flow reserve Hemodynamics Red blood cells Atherosclerosis |
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