Parvovirus B19 Infection Localized in the Intestinal Mucosa and Associated with Severe Inflammatory Bowel Disease |
| |
| Authors: | Loris Pironi Francesca Bonvicini Paolo Gionchetti Antonia D'Errico Fernando Rizzello Catia Corsini Laura Foroni Giorgio Gallinella |
| |
| Affiliation: | Center for Chronic Intestinal Failure, Department of Internal Medicine and Gastroenterology,1. Division of Microbiology, Department of Clinical and Experimental Medicine,2. Center for Inflammatory Bowel Disease, Department of Internal Medicine and Gastroenterology,3. Division of Pathology, Department of Oncology and Hematology,4. Division of Vascular Surgery, Department of Specialistic Surgical and Anesthesiological Sciences, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy5. |
| |
| Abstract: | ![]()
Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bowel disease, characterized by duodenal villous atrophy with increased intraepithelial lymphocytes and inflammatory infiltrates in the colonic mucosa. Virus in the intestinal mucosa was detected in cells of the inflammatory infiltrate, identified as T lymphocytes and selectively localized in sites of active tissue degeneration. |
| |
| Keywords: | |
|
|
