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| HSP27在舌鳞癌中的表达及意义 | |
| 引用本文： | 张宁宁,盛士虎,陈丹,燕王翔,丁学强,王安训. HSP27在舌鳞癌中的表达及意义[J]. 北京口腔医学, 2010, 18(3): 146-148. DOI: 10.3969/j.issn.1006-673X.2010.03.009 |
| 作者姓名： | 张宁宁 盛士虎 陈丹 燕王翔 丁学强 王安训 |
| 作者单位： | 中山大学附属第一医院口腔科,广州,510080;中山大学附属第一医院口腔科,广州,510080;中山大学附属第一医院口腔科,广州,510080;中山大学附属第一医院口腔科,广州,510080;中山大学附属第一医院口腔科,广州,510080;中山大学附属第一医院口腔科,广州,510080 |
| 基金项目： | 广东省科技计划项目基金 |
| 摘 要： | 目的探讨HSP27在舌鳞癌中的表达及意义。方法对19例正常舌黏膜、79例舌鳞癌用免疫组化检测HSP27的表达。对其表达水平进行统计学分析。结果在正常舌粘膜上皮中,HSP27主要位于棘层细胞胞浆,呈棕黄色或黄色颗粒。在舌鳞癌组织中HSP27主要分布于上皮全层,其表达显著高于正常舌黏膜（P〈0.05）,不同分化程度舌鳞癌患者中HSP27的平均表达水平有显著性差异（P〈0.001）,高分化表达水平最高,低分化表达水平最低;不同临床分期以及是否淋巴结转移HSP27的表达无显著差异。结论 HSP27表达的改变可能与舌鳞癌的发生发展有关。 |
| 关 键 词： | 热休克蛋白 舌鳞癌 免疫组化 |
Expression and significance of HSP27 in tongue squamous cell carcinoma |
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| ZHANG Ning-ning,SHENG Shi-hu,CHEN Dan,YAN Wang-xiang,DING Xue-qiang,WANG An-xun. Expression and significance of HSP27 in tongue squamous cell carcinoma[J]. Beijing Journal Of Stomatology, 2010, 18(3): 146-148. DOI: 10.3969/j.issn.1006-673X.2010.03.009 | |
| Authors: | ZHANG Ning-ning SHENG Shi-hu CHEN Dan YAN Wang-xiang DING Xue-qiang WANG An-xun |
| Affiliation: | ZHANG Ning-ning,SHENG Shi-hu,CHEN Dan,YAN Wang-xiang,DING Xue-qiang,WANG An-xun.Department of Stomatology,First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China |
| Abstract: | Objective To investigate the expression of HSP27 in tongue squamous cell carcinoma.Methods The expression of HSP27 was detected by immunohistochemical technique in 79 cases of tongue cancer and 19 normal oral mucosa and statistically analyzed.Results In nomal oral mucosa,HSP27 was stained and located in the strata spinosum.The expression of HSP27 in tongue cancer was significantly higher than in nomal oral mucosa(P<0.001).There was a significant difference among different differentiation,with the well-diffe... |
| Keywords: | HSP27 Tongue squamous cell carcinoma Immunohistochemistry |
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