|
|||||
|
|
| 营养性肥胖大鼠TNF-α、leptin水平和胰岛素敏感指标的研究 | |
| 引用本文： | 王艳,ZHAI Ling-ling,吴辉,姚兴家. 营养性肥胖大鼠TNF-α、leptin水平和胰岛素敏感指标的研究[J]. 中国误诊学杂志, 2008, 8(25): 6057-6058 |
| 作者姓名： | 王艳 ZHAI Ling-ling 吴辉 姚兴家 |
| 作者单位： | 1. 辽宁中医药大学职业技术学院卫生管理系,辽宁,沈阳,110101 2. 中国医科大学公共卫生学院 |
| 摘 要： | 目的：探讨饮食诱导肥胖（DIO）大鼠血清肿瘤坏死因子-α（TNF—α）、瘦素（leptin）和胰岛素敏感指标的变化及意义。方法：采用放免法检测大鼠血清TNF-α和leptin水平。结果：实验3周末，DIO大鼠leptin水平高于对照组（P〈0．05）；实验12周末，DIO大鼠TNF-α和leptin水平均显著高于对照组和DIO—R大鼠（P〈0．01）；DIO大鼠血清TNF-α，leptin水平均和胰岛素敏感指数（ISI）呈负相关（P〈0．05）。结论：TNF-α，leptin可能在肥胖相关的胰岛素抵抗（IR）发生中起协同作用。 |
| 关 键 词： | 肥胖症/血液 肿瘤坏死因子α/分析 瘦素/血液 胰岛素抗药性 大鼠 随机分配 动物 |
Study on Levels of TNF-α,Leptin and Insulin Sensitivity Index in Obese Rats |
|
| ZHAI Ling-ling. Study on Levels of TNF-α,Leptin and Insulin Sensitivity Index in Obese Rats[J]. Chinese Journal of Misdiagnostics, 2008, 8(25): 6057-6058 | |
| Authors: | ZHAI Ling-ling |
| Affiliation: | WANG Yan,ZHAI Ling-ling,WU Hui,et al. (Department of Health Management,College of Professional Technique, Liao Ning University of Traditional Chinese Medicine ,Shenyang 110101,China) |
| Abstract: | Objective：To study the levels of serum tumor necrosis factor -α（TNF-α）,leptin and insulin sensitivity index （ISI） in diet induced obesity （DIO） rats. Methods：The levels of serum TNF-α and leptin were measured by radioimmunoassay. Results ：In the third week ,the level of serum leptin of DIO rats was higher than that of the control rats （P〈0.05） ;In the twelfth week ,the concentrations of serum TNF-α and leptin were significantly higher in DIO rats than those in control and DIO-R rats （P〈0.01）;ISI was in negative correlation with the levels of serum TNF-α and leptin in DIO rats （P〈0.05）. Conclusion：TNF-α may be in cooperation with leptin m insulin resistance, IR） related to obesity. |
| Keywords: | Obesity/blood Tumor Necrosis Factor-alpha/analysis Leptin/blood Insulin Resistance Rats ： Random Allocation Animals |
| 本文献已被 维普 万方数据 等数据库收录！ | |