端粒酶在肾上腺皮质肿瘤中的表达及其临床意义

为了解端粒酶在肾上腺皮质肿瘤中的表达及其临床意义 ,采用PCR为基础的端粒重复序列扩增法对 8例肾上腺皮质癌、2 0例肾上腺皮脂腺瘤、2 4例瘤旁组织以及 4例正常肾上腺组织进行了检测。结果显示 ,8例肾上腺皮质癌组织中端粒酶表达阳性 7例 ;瘤旁组织端粒酶表达阳性 1例 ;2 0例肾上腺皮脂腺瘤及所有正常肾上腺组织端粒酶表达均阴性。研究表明 ,肿瘤中端粒酶活性表达反映了肿瘤细胞的恶性行为 ;端粒酶活性检测可望成为肾上腺皮质肿瘤良恶性诊断的一种有用方法

THE EXPRESSION OF TELOMERASE IN ADRENAL CORTICAL TUMORS AND ITS CLINICAL SIGNIFICANCE

To study the telomerase expression in adrenal cortical tumors and its clinical signinificance. Telomerase expression was estimated in 8 cases of adrenal cortical carcinoma, 20 cases of adrenal cortical adenoma, 24 tissues adjacent to cancer, and 4 specimens of normal adrenal tissue by the PCR based telomeric repeat amplification protocol. Telomerase was found to be expressed positively in 7(87 5%) of 8 adrenal cortical carcinoma samples and 1(4 2%) of 24 tissues adjacent to tumor, while it was not expressed in all the 20 samples of adrenal cortical adenoma and normal adrenal tissue. The expression of telomerase in adrenal cortical tumors clearly demonstrated the malignant behavior of the tumor cells. Demonstration of telomerase expression appears to be a useful tool for the diagnosis of malignant adrenal cortical tumors.