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| 大鼠肺缺血再灌注损伤时CXCL9因子的表达 | |
| 引用本文： | 张莉娟,李建强,高菡,赵卉. 大鼠肺缺血再灌注损伤时CXCL9因子的表达[J]. 中国现代医生, 2011, 49(9): 10-11 |
| 作者姓名： | 张莉娟 李建强 高菡 赵卉 |
| 作者单位： | 山西医科大学第二医院呼吸内科,山西太原,030001 |
| 基金项目： | 山西省留学人员管理委员会科研资助项目，山西省科技攻关项目 |
| 摘 要： | 目的探讨大鼠肺缺血再灌注损伤时CXCL9因子的表达和中介素1-53（IMD1—53）对其的影响。方法建立大鼠在体肺缺血再灌注模型。将72只健康的Wistar大鼠随机分为3组：假手术组（c组）、缺血再灌注组（IR组）、中介素1—53组（IMD组）。每组取缺血45min、再灌注60min、再灌注120min时点各8只大鼠留取血浆及右肺组织。ELISA法检测血浆中CXCL9的含量，组织学评价肺组织损伤。结果IMD组血浆中CXCL9因子的表达均低于IR组，组织学变化显示预先给予IMD1—53可减轻肺缺血再灌注损伤。结论IMD1—53对肺缺血再灌注损伤有保护作用，其作用机制可能为减少趋化因子CXCL9因子的表达。 |
| 关 键 词： | 肺 缺血再灌注 CXCL9 中介素1—53 |
Expression of CXCL9 during Lung Ischemia Reperfusion Injury in Rats |
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| ZHANG Lijuan,LI Jianqiang,GAO Han,ZHAO Hui. Expression of CXCL9 during Lung Ischemia Reperfusion Injury in Rats[J]. , 2011, 49(9): 10-11 | |
| Authors: | ZHANG Lijuan LI Jianqiang GAO Han ZHAO Hui |
| Affiliation: | ZHANG Lijuan LI Jianqiang GAO Han ZHAO Hui Department of Respiratory Medicine,the Second Affiliated Hospital of Shanxi Medical University,Taiyuan 030001,China |
| Abstract: | Objective To investigate the expression of CXCL9 in lung ischemia reperfusion injury in rats and the effect of IMD1-53 on it.Methods Rat lung model of ischemia reperfusion injury was established in vivo.Seventy-two healthy wistar rats were randomly divided into three groups: sham surgical control(C group),ischemia reperfusion group(IR group),IMD1-53 group(IMD group).The plasma sample and the right lung were collected at different three time points: 45 min ischemia,60 min and 120 min reperfusion(8 rats in ea... |
| Keywords: | CXCL9 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |