高频重复经颅磁刺激对脑卒中后非痴呆型血管性认知障碍患者的疗效观察

目的:探讨高频重复经颅磁刺激(rTMS)对脑卒中后非痴呆型血管性认知障碍患者认知功能的影响。方法:入选脑卒中后非痴呆型血管性认知障碍(VCIND)患者60例,随机将其分为观察组和对照组各30例,2组患者均给予药物治疗和常规康复训练,观察组在此基础上增加高频rTMS治疗。2组患者均于治疗前、治疗6周后进行简易精神状态量表(MMSE)、蒙特利尔认知评估量表(MOCA)和改良Barthel指数(MBI)评定。结果:治疗后,2组患者的MMSE、MOCA及MBI评分均较治疗前明显提高(P0.05),观察组上述评分较对照组提高更明显(P0.05)。结论:高频rTMS可改善脑卒中后非痴呆型血管性认知障碍患者的认知功能以及进食、个人卫生、洗澡、穿衣、如厕、上下楼梯和平地步行等日常生活自理能力。

Therapeutic effects of high frequency repetitive transcranial magnetic stimulation in treating vascular cognitive impairment after stroke but no dementia

Objective: To explore the effect of high frequency repetitive transcranial magnetic stimulation (rTMS) on the cognitive function of patients with vascular cognitive impairment after stroke but no dementia. Methods: Sixty patients with vascular cognitive impairment after stroke but no dementia (VCIND) were randomly divided into an observation group and a control group, each of 30. Both two groups of patients were given drug therapy and routine rehabilitation training. The observation group was additionally given high frequency rTMS. Both two groups of patients were assessed by the mini-mental state examination (MMSE), the Montreal cognitive assessment (MOCA) and the modified Barthel index (MBI) before and 6 weeks after the treatment. Results: After the treatment, the MMSE, MOCA and MBI scores of two groups were significantly higher than those before treatment (P<0.05). The MMSE and MOCA scores in the observation group were increased more significantly than in the control group (P<0.05). Conclusion: High frequency rTMS can improve cognitive function and daily life activities ability of patients with VCIND.