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| 中国被毛孢菌丝体对小鼠免疫功能的影响 | |
| 引用本文： | 葛飞,桂琳,李婉珍,樊美珍.中国被毛孢菌丝体对小鼠免疫功能的影响[J].中国临床药理学与治疗学,2008,13(8):852-855. |
| 作者姓名： | 葛飞 桂琳 李婉珍 樊美珍 |
| 作者单位： | 1. 安徽农业大学微生物防治省重点实验室,合肥,230036,安徽;安徽工程科技学院生物与化学工程系,芜湖,241000,安徽 2. 皖南医学院微生物和免疫学教研室,芜湖,241001,安徽 3. 安徽工程科技学院生物与化学工程系,芜湖,241000,安徽 4. 安徽农业大学微生物防治省重点实验室,合肥,230036,安徽 |
| 基金项目： | 安徽工程科技学院引进人才科研启动基金 |
| 摘 要： | 目的：研究中国被毛孢菌丝体对小鼠免疫功能的影响。方法：分别给予中国被毛孢菌丝体50、200和800mg／kg灌胃，连续用药5d，进行小鼠碳粒廓清试验、血清溶血素试验和二硝基氟苯（DNFB）诱导小鼠迟发性变态反应（DTH）。结果：中国被毛孢菌丝体在200mg／kg和800mg／kg剂量下，能明显增强小鼠单核-巨噬细胞吞噬功能、体液免疫功能和细胞免疫功能，且有显著剂量依赖性。结论：中国被毛孢菌丝体有明显的免疫促进作用。 |
| 关 键 词： | 中国被毛孢 菌丝体 免疫调节 |
Study on effects of Hirsutella sinensis fermented mycelia on immunologic function in mice |
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| GE Fei,GUI Lin,LI Wan-zhen,FAN Mei-zhen.Study on effects of Hirsutella sinensis fermented mycelia on immunologic function in mice[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2008,13(8):852-855. | |
| Authors: | GE Fei GUI Lin LI Wan-zhen FAN Mei-zhen |
| Institution: | GE Fei, GUI Lin, LI Wan-zhen, FAN Mei-zhen (1.Anhui Provincial Key Laboratory of Microbial Pest Control, Anhui Agricultural University, Hefei 230036, Anhui, China ; 2.Department of Biochemical Engineering, Anhui University of Science and Technology, Wuhu 241000, Anhui , China ; 3.Department of Microbiology and Immunology, Wannan Medical College, Wuhu 241001, Anhui , China) |
| Abstract: | AIM： To investigate the effects of Hirsutella sinensis fermented mycelia on immunologic function in mice. METHODS： The mice were reared with Hirsutella sinensis fermented mycelia at the doses of 50, 200 and 800 mg/kg for 5 days for tests of carbon clearance, serum haemolysin and delayed-type hypersensitivity （DTH） induced by 2-dinitro fluoro benzene （DNFB）. RESULTS： The medium and high doses of 200 and 800 mg/kg enhanced phagocytosis by uninucleate macrophages, humoral immunity and cellular immunity of mice significantly with obvious dose dependence. CONCLUSION： These results suggest that the Hirsutella sinensis fermented mycelia has substantial immunoregulation function. |
| Keywords: | Hirsutella sinensis mycelia immunoregulation |
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