| 类风湿关节炎动物模型与临床的关系 |
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| 引用本文： | 张玲玲,沈玉先,魏伟.类风湿关节炎动物模型与临床的关系[J].中国药理学通报,2002,18(5):502-506. |
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| 作者姓名： | 张玲玲 沈玉先 魏伟 |
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| 作者单位： | 安徽医科大学临床药理研究所,合肥,230032 |
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| 基金项目： | “十五”科技攻关项目，合肥市攻关项目及重点课题，安徽省自然科学基金资助 (No 0 180 3 0 2 6) |
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| 摘 要： | 类风湿关节炎 (rheumatoidarthritis,RA)动物模型特别是大鼠佐剂性关节炎模型和小鼠胶原诱导性关节炎模型与人RA在发病机制、临床表现等有着相似的特点 ,是研究RA、筛选抗炎免疫药物较理想的病理模型。探讨RA动物模型的发病机制及其与临床的关系 ,对进一步了解RA的病理、生理、神经内分泌免疫等特点 ;对寻找安全有效的治疗RA的药物十分重要。该文就几种RA动物模型的建立、病理特征、临床表现等方面进行了论述
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| 关 键 词： | 类风湿关节炎 佐剂性关节炎 胶原诱导性关节炎 |
| 文章编号： | 1001-1978(2002)05-0502-05 |
| 修稿时间： | 2001年11月15 |
Relation between animal models of RA and clinic |
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| ZHANG Ling Ling,SHEN Yu Xian,WEI Wei.Relation between animal models of RA and clinic[J].Chinese Pharmacological Bulletin,2002,18(5):502-506. |
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| Authors: | ZHANG Ling Ling SHEN Yu Xian WEI Wei |
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| Abstract: | Animal models of rheumatoid arthritis(RA)especially adjuvant arthritis(AA)in rats and collagen induced arthritis(CIA)in mice have much character similar to human RA in pathological mechanism,clinical representation and so on. The models are more ideal in investigating RA and selecting drugs of anti inflammation and immunity. To discuss the pathological mechanism and the relation between animal models of RA and clinic will be important not only to research RA in pathology,physiology,nervous endocrine immunity and so on,but also to find out safety and effective drugs of treatment RA. The articl summarizes several animal models of RA in establishment,pathological and clinical changes,inflammatory immune regulation and so on. |
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| Keywords: | theumatoid artritis adjuvant arthritis collgen induced arthritis |
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