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| 尼莫地平与泊洛沙姆固体分散体的制备及其体外溶出度 | |
| 引用本文： | 戴叶军 陆锦芳. 尼莫地平与泊洛沙姆固体分散体的制备及其体外溶出度[J]. 中国医药工业杂志, 1998, 29(12): 550-552 |
| 作者姓名： | 戴叶军 陆锦芳 |
| 作者单位： | 上海医科大学药剂教研室 |
| 摘 要： | 采用熔融法制备尼莫地平（１）与泊洛沙姆（２）固体分散体，并测定其体外溶出度，结果均高于１原药。１与２不同比例（１∶１、１∶２、１∶３、１∶５、１∶１０）的固体分散体４５ｍｉｎ时的溶出度分别是原药的６．８、７．３、７．６、８．５、９．８倍。ＤＳＣ测定结果表明，１－２固体分散体的ＤＳＣ曲线中１原药的熔点峰消失。 |
| 关 键 词： | 尼莫地平 泊洛沙姆 固体分散体 |
PREPARATION AND DISSOLUTION OF NIMODIPINE POLOXAMER SOLID DISPERSIONS |
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| DAI Ye Jun,LU Jin Fang,ZHEN Ji Hua,TANG Yu Wen. PREPARATION AND DISSOLUTION OF NIMODIPINE POLOXAMER SOLID DISPERSIONS[J]. , 1998, 29(12): 550-552 | |
| Authors: | DAI Ye Jun LU Jin Fang ZHEN Ji Hua TANG Yu Wen |
| Abstract: | The solid dispersions of 5 different proportions of nimodipine and polo xamer were prepared by melting method. The dissolution of the solid dispersions was higher than the nimodipine powder. Their dissolutions in 45 minutes were 6.9,7.3,7.6,8.5,9.8 times that of the powder respectively. The melting point peak of nimodipine was not observed in DSC curves of the solid dispersion. |
| Keywords: | nimodipine poloxamer solid dispersion |
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