COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort |
| |
| Affiliation: | 1. Department of Surgery, University of California San Francisco, San Francisco, CA, United States;2. Histocompatibility and Molecular Immunogenetics Laboratory, Emory University, Atlanta, GA, United States;3. Medstar-Georgetown Transplant Institute, Washington, DC, United States;4. Immunogenetics and Transplantation Laboratory Houston Methodist, Houston, TX, United States;5. Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, San Antonio, San Antonio, TX, United States;6. Department of Laboratory Medicine, University of Alabama Medical Center, Birmingham, AL, United Kingdom;7. Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States;8. Department of Surgery, University of Alabama Medical Center, Birmingham, AL, United Kingdom;9. Department of Surgery, University of Southern California, Los Angeles, CA, United States;10. Department of Medicine, Division of Nephrology, University of Alabama, Birmingham, AL, United Kingdom;11. Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, United States;12. Department of Surgery, Emory University School of Medicine, Atlanta, GA, United States;13. Department of Pathology, Massachusetts General Hospital, Boston MA, United States;14. Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States;15. Department of Surgery, Massachusetts General Hospital, Boston, MA, United States;p. Department of Pathology, MedStar Georgetown University Hospital, Washington, DC, United States;q. Department of Surgery, Houston Methodist, Houston, TX, United States;r. Immunogenetics and Transplantation Laboratory, Department of Surgery, University of California San Francisco, San Francisco, CA, United States |
| |
| Abstract: | Although rare, infection and vaccination can result in antibodies to human leukocyte antigens (HLA). We analyzed the effect of SARS-CoV-2 infection or vaccination on HLA antibodies in waitlisted renal transplant candidates. Specificities were collected and adjudicated if the calculated panel reactive antibodies (cPRA) changed after exposure. Of 409 patients, 285 (69.7 %) had an initial cPRA of 0 %, and 56 (13.7 %) had an initial cPRA > 80 %. The cPRA changed in 26 patients (6.4 %), 16 (3.9 %) increased, and 10 (2.4 %) decreased. Based on cPRA adjudication, cPRA differences generally resulted from a small number of specificities with subtle fluctuations around the borderline of the participating centers’ cutoff for unacceptable antigen listing. All five COVID recovered patients with an increased cPRA were female (p = 0.02). In summary, exposure to this virus or vaccine does not increase HLA antibody specificities and their MFI in approximately 99 % of cases and 97 % of sensitized patients. These results have implications for virtual crossmatching at the time of organ offer after SARS-CoV-2 infection or vaccination, and these events of unclear clinical significance should not influence vaccination programs. |
| |
| Keywords: | Kidney transplantation Organ allocation Virtual crossmatch COVID-19 vaccination SARS-CoV-2 infection COVID-19" },{" #name" :" keyword" ," $" :{" id" :" k0045" }," $$" :[{" #name" :" text" ," _" :" coronavirus disease 2019 cPRA" },{" #name" :" keyword" ," $" :{" id" :" k0055" }," $$" :[{" #name" :" text" ," _" :" calculated panel reactive antibodies ESRD" },{" #name" :" keyword" ," $" :{" id" :" k0065" }," $$" :[{" #name" :" text" ," _" :" end-stage renal disease HLA" },{" #name" :" keyword" ," $" :{" id" :" k0075" }," $$" :[{" #name" :" text" ," _" :" human leukocyte antigen MFI" },{" #name" :" keyword" ," $" :{" id" :" k0085" }," $$" :[{" #name" :" text" ," _" :" mean fluorescence intensity SAB" },{" #name" :" keyword" ," $" :{" id" :" k0095" }," $$" :[{" #name" :" text" ," _" :" single antigen bead SARS-CoV-2" },{" #name" :" keyword" ," $" :{" id" :" k0105" }," $$" :[{" #name" :" text" ," _" :" Severe acute respiratory syndrome coronavirus 2 |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
