血小板相关参数对恶性肿瘤合并静脉血栓栓塞的诊断价值

目的：探讨血小板相关参数对恶性肿瘤合并静脉血栓栓塞的诊断价值。方法：恶性肿瘤118例，其中血栓组58例，非血栓组60例，60例门诊健康体检者作为正常对照组，比较各组外周血血小板参数特点。结果：入院时检测血栓组血小板平均体积（MPV）及血小板分布宽度（PDW）分别为（8．7±1．0）fl、（12．6±1．4）％，非血栓组MPV及PDW分别为（8．8±1．3）fl、（12．8±1．4）％，正常对照组MPV及PDW分别为（8．0±1．1）fl、（11．5±1．9）％，血栓组及非血栓组外周血MPV及PDW水平要显著高于正常对照组（P＜0．05）。血栓组于血栓检出时检测MPV及PDW分别为（10±1．6）fl、（14．1±1．8）％，同期检测非血栓组MPV及PDW分别为（9．28±1．6）fl、（13．3±1．6）％，血栓组MPV及PDW要显著高于非血栓组（P＜0．05），两次检测血栓组外周血MPV及PDW变化的百分比要显著高于非血栓组（P＜0．05）。结论：血栓组患者外周血MPV、PDW及其变化百分比明显增高，提示这些指标对早期预测恶性肿瘤并发血栓形成有重要作用。

Diagnostic value of peripheral platelet indices for malignant tumor with thrombosis

Objective:To investigate the diagnostic value of peripheral platelet indices for malignant tumor with thrombosis.Methods:All 118 cases ofmalignant tumor patients were selected.Thrombosis group consisted of58 cases of malignant tumor with thrombosis,and non-thrombotic group consisted 60 cases of malignant tumor without throm-bosis.60 cases of healthy outpatients were in the control group.The characteristics of peripheral blood platelet parame-ters of the three groups were analyzed.Results:At admission,the thrombosis group's mean platelet volume (MPV) and platelet distribution width (PDW)were(8.7 ±1.0)fl and (12.6 ±1.4)%,respectively,and the MPV and PDW in the non thrombotic group were (8.8 ±1.3)fl and (12.8 ±1.4)%,while in the control group were (8.0 ± 1.1 )fl and (11.5 ±1.9)%.The MPV and PDW in the thrombosis group and in the non thrombotic group were sig-nificantly higher than the control group (P<0.05 ).While thrombosis were detected ,the MPV and PDW in the thrombosis group were (10 ±1.6)fl and (14.1 ±1.8)%,and those in the non thrombotic group were (9.28 ±1.6) fl and (13.3 ±1.6)%,respectively.MPV,PDW and percent changes in MPV and PDW were dramatically higher in the thrombosis group than in the non thrombotic group (P<0.05 ).Conclusion:Measurements of MPV,PDW and percent changes in MPV and PDW appears to be useful markers for predicting venous thrombosis in malignant pa-tients.