结直肠腺瘤、腺癌与腰围及腰臀比的关系

目的：研究腰围（WC）、腰臀比（WHR）与结直肠腺瘤、腺癌危险性之间的关系。方法：采用病例对照研究。所有结直肠腺瘤、腺癌的患者均查结肠镜活检病理证实，对照为与病例相同医院的同期就诊，结肠镜结果正常健康人群。观察组与对照组各140例，1∶1匹配。同时对腰围和臀围进行测量。采用多元 Logistic 回归模型对患者腰围、腰臀比与结直肠腺瘤、腺癌的比值比（OR）及其相应的95％可信区间进行估计。结果：腹型肥胖者（腰围＞85 cm）与正常腰围者（腰围≤85 cm ）相比，发生结直肠腺瘤、腺癌的 OR ＝0．98，95％CI：0．91～1．33；与正常体型者（腰臀比＜0．9）相比较，向心性肥胖者（腰臀比≥0．9）与发生结直肠腺瘤、腺癌的危险性增加有关（OR ＝1．16，95％CI：1．02～1．87，P ＜0．05）。结论：向心性肥胖为结直肠腺瘤、腺癌的一个危险因素。

Association of waist circumference,waist -to -hip ratio with colorectal adenomas,ade-nocarcinoma

Objective:To examine the association between waist circumference (WC),waist -to -hip ratio (WHR)and colorectal adenomas,adenocarcinoma.Methods:A hospital -based case control study was conducted. Cases(n =140)in observation group were confirmed adenoma or adenocarcinoma,and controls(n =140)were normal healthy people.Results:The difference between abdominal obesity males(WC >85cm)and those normal waist circ-umference (WC≤85cm)was not significant(OR =0.98,95%CI:0.91 ~1.33).WHR≥0.9 was positively related to colorectal adenomas,adenocarcinoma(compared with WHR <0.9:OR =1.16,95%CI:1.02 ~1.87,P <0.05). Conclusion:Obesity,especially central obesity,is an important risk factor for colorectal adenomas,adenocarcinoma.