熊果酸诱导自噬及其在妇科肿瘤中的研究进展

肿瘤的治疗一直是临床上一大难题，植物成分紫杉醇、长春新碱等有效抗肿瘤中药的出现为探寻此类新药指明了新的方向。熊果酸是从多种天然植物中提取出来的，是具有较强生物活性和广泛药理学作用的一种五环三萜类弱酸型化合物。近年来发现熊果酸的抗肿瘤作用包括细胞毒作用、抗血管生成作用、诱导肿瘤细胞分化成熟、抑制肿瘤细胞迁移和转移、逆转多药耐药以及促进肿瘤细胞自噬和凋亡等多种复杂的分子机制。本文就熊果酸的理化性质、调控细胞自噬与凋亡作用及其在妇科恶性肿瘤中的研究进展作一综述。

Progress of UA-initiated autophagic and apoptotic effects in gynecological malignant tumors

Cancer treatment has been a major problem in clinical.Plant components like paclitaxel and vincristine have exhibited strong anti-tumor effects and this has guided a new direction to find more effective anti-tumor drugs.Ursolic acid (UA) is a weak-acid pentacyclic triterpene,owning high biological activity and broad pharmacological effects,which can be extracted from a variety of natural plants.Recently,UA has been proven to prompt antitumor activities through multiple complex molecular mechanism,including cytotoxicity,anti-angiogenesis,inducing tumor cell differentiation,inhibiting tumor migration and metastasis,reversing multidrug resistance as well as promoting tumor cell autophagy and apoptosis.This paper introduces the physical and chemical properties of UA,proposes the mechansim of UA induced cancer cell autophagy and apoptosis,and casts its research progress against gynecologic malignant tumors.