| 唑来膦酸治疗乳腺癌及其骨转移的研究进展 |
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| 引用本文： | 杨慧,邱玲,林建国,郭刘斌,谢敏浩. 唑来膦酸治疗乳腺癌及其骨转移的研究进展[J]. 现代肿瘤医学, 2016, 0(8): 1306-1310. DOI: 10.3969/j.issn.1672-4992.2016.08.040 |
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| 作者姓名： | 杨慧 邱玲 林建国 郭刘斌 谢敏浩 |
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| 作者单位： | 1. 南京医科大学第一附属医院放疗科,江苏南京 210029;江苏省原子医学研究所、卫生部核医学重点实验室,江苏无锡 214063;2. 江苏省原子医学研究所、卫生部核医学重点实验室,江苏无锡,214063 |
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| 基金项目： | 国家自然科学基金资助项目(21371082)，江苏省自然科学基金资助项目(BK20141102)，江苏省医学重点人才培养资助项目(RC2011097) |
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| 摘 要： | 唑来膦酸是第三代含氮双膦酸盐类药物的典型代表,在已上市的双膦酸盐类药物中其综合疗效最好,不仅可以通过抑制甲羟戊酸途径直接作用于破骨细胞,也可直接或间接对肿瘤细胞产生抑制作用.乳腺癌属于易发生骨转移的一类恶性肿瘤,大量研究表明唑来膦酸对乳腺癌骨转移具有一定的疗效,可缓解骨痛,目前其已被纳入乳腺癌骨转移的临床常规治疗中,同时唑来膦酸在辅助性内分泌治疗乳腺癌时亦发挥重要的作用.本文就唑来膦酸对乳腺癌骨转移治疗方面的相关研究进展做一综述.
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| 关 键 词： | 唑来膦酸 治疗乳腺癌 骨转移 |
Research progress on the treatment of zoledronic acid on breast cancer and the related skeletal metastases |
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| Abstract: | Zoledronic acid,the typical third-generation bisphosphonates,has outstanding therapeutic effect among the bisphosphonates. It not only exerts effects on osteoclasts by inhibiting key enzymes in the mevalonate pathway di-rectly,but also induces antitumor activities directly or indirectly. Breast cancer is more prone to develop skeletal me-tastases among various malignant tumors. The extensive preclinical evidence showed that zoledronic acid has therapeu-tic effect on breast cancer and the related skeletal metastases,and it has been licensed for the clinical treatment. In this article,the research progress on the treatment of zoledronic acid on breast cancer and the related skeletal metasta-ses were reviewed. |
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| Keywords: | zoledronic acid treatment breast cancer skeletal metastases |
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