NP方案治疗晚期非小细胞肺癌的临床观察

目的：观察长春瑞滨（NVB）加顺铂（DDP）联合化疗，治疗晚期非小细胞肺癌（NSCLC）的临床效果。方法：选择非小细胞肺癌58例，男42例、女16例，方案NVB 25mg／m^2，静滴d1—8，DDP20mg／m^2d 1—5静滴。结果：PR28例、NC27例、PD3例，总有效率48．27％。主要毒副作用为骨髓抑制白细胞下降占81．03％，其中Ⅲ—Ⅳ白细胞下降率为36．21％，消化道反应发生率53．44％，大多数较轻，局部疼痛或静脉炎的发生率27．58％。结论：长春瑞滨（NVB）加顺铂联合化疗治疗晚期NSCLC有效率高，毒性反应可以耐受，值得临床研究应用。

Homemade vinorelbine based combination chemotherapy in non- small- call lung cancer

Objective:To evaluate the results of combination chemotherapy with vinorelbine(NVB) plus cisplatin(DDP) in the treatment of non-small-cell lung cancer(NSCLC).Methods:fifty-eight patients with advanced NSCLC were enrolled in this study.Adenocarcinoma was the most common type of malignancy.Results: The overall rate was 48.27%.The does limiting toxicity was neutropenia,which was seen 81.03% in treated cases.The local venous toxicity was observed in 27.58% of the patients.Conclusions: A high response rate was obtained in advanced NSCLC treated by NVB plus DDP.NVB is a promising antitumor agent with tolerable toxicity.