胆汁反流和幽门螺杆菌感染在胆汁反流性胃炎和消化性溃疡发病中的作用

目的探讨胆汁反流和幽门螺杆菌感染在胆汁反流性胃炎和消化性溃疡发病中的作用。方法采用病理组织学检查和快速尿素酶试验对76例胆汁反流性胃炎及22例兼有胆汁反流性胃炎和消化性溃疡的患者行幽门螺杆菌检测,并与29例消化性溃疡患者作对照。结果胆汁反流性胃炎组幽门螺杆菌阳性率为31.6%(24/76例),兼有胆汁反流性胃炎和消化性溃疡组幽门螺杆菌阳性率为59.0%(13/22例),消化性溃疡组幽门螺杆菌阳性率为72.4%(21/29例),前二组比较,差异有显著意义(P<0.05),后二组比较,差异无显著意义(P>0.05)。结论胆汁反流在胆汁反流性胃炎的发病中起主要作用,幽门螺杆菌感染在消化性溃疡的发病中起主要作用。胆汁反流和幽门螺杆菌感染在胆汁反流性胃炎和消化性溃疡的共同发病中互不明显影响,幽门螺杆菌感染所起的作用可能更大一些。

Role of bile reflux and Helicobacter pylori infection in bile reflux gastritis and peptic ulcer

Objective] To evaluate the role of bile reflux and Helicobacter pylori infection in bile reflux gastritis and peptic ulcer. Methods] 76 patients with bile reflux gastritis and 22 patients both with bile reflux gastritis and peptic ulcer were elevated. Helicobacter pylori infection was determined by both histology(Giemsa staining) and rapid urease test (RUT). 29 patients with peptic ulcer were as controls. Results] Patients with bile reflux gastritis had 31.6% (24/76 cases) Helicobacter pylori positive rate, patients both with bile reflux gastritis and peptic ulcer had 59.0% (13/22 cases) Helicobacter pylori positive rate, patients with peptic ulcer had 72.4% (21/29 cases) Helicobacter pylori positive rate, the Helicobacter pylori positive rate of bile reflux gastritis and peptic ulcer group was significantly increased as compared with that of bile reflux gastritis (P <0.05), however with no significance between bile reflux gastritis and peptic ulcer group and peptic ulcer group (P >0.05). Couclusion] Bile reflux has primary effect in bile reflux gastritis, Helicobacter pylori infection has primary effect in peptic ulcer. Bile reflux and Helicobacter pylori infection have no significant effect between bile reflux gastritis and peptic ulcer. Helicobacter pylori may be have a great effect.