| E-cad在胃癌中的表达及其临床意义 |
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| 引用本文： | 张闻辉,王舒宝. E-cad在胃癌中的表达及其临床意义[J]. 癌症进展, 2005, 3(6): 602-604,527 |
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| 作者姓名： | 张闻辉 王舒宝 |
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| 作者单位： | 天津市第一中心医院移植科;中国医科大学附属第一医院肿瘤科,天津,300192 |
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| 摘 要： | 目的探讨E-cad在胃癌中的表达与胃癌生物学行为之间的关系.方法应用免疫组织化学方法(S-P法),对上皮-钙粘附素(E-cad)在38例胃癌组织及正常胃组织中的表达情况进行了检测.结果E-cad在所有正常胃粘膜上皮组织中均见表达;而在胃癌组织中,E-cad的表达则呈现不同程度的改变,包括保留表达、异质性表达,消失表达;且与胃癌的大体类型、分化程度、生长方式、癌的侵袭深度,以及淋巴结是否转移等存在着相关性.结论E-cad在胃癌中的表达减弱,与胃癌侵袭转移密切相关.
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| 关 键 词： | 胃癌 E-cad 侵袭 转移 |
Expression of E-cad in gastric carcinoma and its clinical significance |
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| Zhang Wenhui,Wang Shubao. Expression of E-cad in gastric carcinoma and its clinical significance[J]. Oncology Progress, 2005, 3(6): 602-604,527 |
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| Authors: | Zhang Wenhui Wang Shubao |
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| Abstract: | Objective To determine the relationship of E-cad expression in gastric carcinoma with gastric carcinoma behaviour.Methods Streptacidin/peroxidase(SP)technique was used to examine the expression of E-cad in 38 cases of gastric carcinoma and normal gastric tissue.Results E-cad expressed in all normal gastric tissue;expression of E-cad showed positive,heterogeneous and negative type in gastric carcinoma,it related with the gross type,growth type,invasive depth,and lymph node metastasis of gastric carcinoma.Conclusion Down-expression of E-cad in gastric carcinoma significantly related with invasion and metastasis of gastric carcinoma. |
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| Keywords: | gastric carcinoma E-cad invasion metastasis |
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