Foxp3在Treg细胞的表达与结直肠癌预后的研究进展

影响结直肠癌(Colorectal cancer,CRC)患者预后的因素除了一些临床病理学因素外,各类宿主免疫反应也成为影响预后的关键因素。因而,结直肠癌治疗方式除了传统的治疗模式之外,抗肿瘤免疫治疗逐渐成为当前治疗热点。调节性T细胞(Regulatory T,Treg)通过免疫调节机制参与免疫反应过程,并发挥重要的作用。叉头转录因子3(Forkhead box P3,Foxp3)作为调节性T细胞表达的调控因子之一,对Treg细胞通过抑制多种免疫细胞的增殖分化来发挥重要的作用。Foxp3⁺Treg细胞在结直肠癌患者中的表达与预后关系密切。该综述旨在阐明Foxp3与Treg细胞的基本特征、Foxp3⁺Treg细胞发挥肿瘤抑制性作用的机制、Foxp3在Treg细胞中表达对结直肠癌患者预后的重要意义进行阐述。

The relationship between expression of Foxp3 in Treg cells with the prognosis of patients with colorectal cancer

In addition to the traditional treatment mode of colorectal cancer(Colorectal cancer,CRC),anti tumor immune treatment gradually becomes the focus.In addition to some clinical pathological factors which affect the prognosis of colorectal carcinoma,the host′s immune response becomes a hotspot.Treg cells involves in immune reaction through immunomodulatory mechanism.Foxp3 as a regulator of Treg plays an important role though suppress proliferation and differentiation of immune cell.The relationship between the expression of Foxp3 in Treg and prognosis in patients with colorectal cancer is closely.The review is to clarify the basic characters of Foxp3 and Treg,the mechanism of Foxp3+Treg cell,the significance between the expression of Foxp3 in Treg and the prognosis of colorectal cancer.