瘦素受体基因变异与肿瘤遗传易感性研究进展

瘦素（leptin，LEP）是一种脂肪细胞释放的循环激素，与瘦素受体（leptin receptor，LEPR）结合发挥其生理作用。参与调节能量代谢、生殖、血管生成和免疫过程等。基础研究和流行病学研究证明，新血管的形成与肿瘤的发生、发展和预后密切相关。LEPR广泛分布于人体组织的各个部位，并已发现其存在多种基因多态性。最近各国学者对LEPR基因多态性与肿瘤易感性关系进行了大量的病例对照研究，结果显示两者之间存在一定的关系。本文就瘦素受体基因多态性与肿瘤关系的最新研究进展作一综述。

Research progress of leptin receptor genetic polymorphisms and susceptibility to cancers

Leptin （LEP） is a circulating hormone produced by fat cells,which binds with leptin receptor (LEPR) to exert its physiological effect.Leptin is involved in the regulation of energy metabolism,reproduction,angiogenesis,and immune processes.Basic study and epidemiological research have proved that the forming of new blood vessels is closely related to the happening,development,and prognosis of tumor.LEPR is widely distributed all over the body tissue,and has been found many genes polymorphis.Recently,foreign and native scholars have carried out many case-control researches about the relationship between the tumor susceptibility and LEPR genetic polymorphisms,clue to that there are some relationship between them.Here,the article reviews the function of new research development in LEPR gene polymorphism for tumor.